Parathyroid Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Metastatic Parathyroid Cancer
Metastatic disease can appear shortly after the initial diagnosis and operation or for up to 20 years later. Because of the difficulty in making a histologic diagnosis, the appearance of recurrent or metastatic disease in a patient previously operated on for hypercalcemia can be the first indicator that the tumor was malignant. Approximately 50% of the patients who experience recurrence will have distant metastases. The most common site of distant metastasis is the lung.[4,5] Some patients experience years of survival even after the diagnosis of distant metastases. Aggressive surgical resection has been associated with a 30% long-term survival in retrospective series.[3,6] (Refer to the PDQ summary on Hypercalcemia for more information.)
For more information from the National Cancer Institute about multiple myeloma and other plasma cell neoplasms, see the following:
Multiple Myeloma/Other Plasma Cell Neoplasms Home Page
What You Need to Know About™ Multiple Myeloma
Drugs Approved for Multiple Myeloma and Other Plasma Cell Neoplasms
Targeted Cancer Therapies
Understanding Cancer Series: Targeted Therapies (Advances in Targeted Therapies and Targeted Therapies for Multiple Myeloma)
Bone Marrow Transplantation a...
Chemotherapy. Anecdotal reports show that short-term remissions with chemotherapy are possible.[5,10]
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with metastatic parathyroid cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
Wynne AG, van Heerden J, Carney JA, et al.: Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 71 (4): 197-205, 1992.
Busaidy NL, Jimenez C, Habra MA, et al.: Parathyroid carcinoma: a 22-year experience. Head Neck 26 (8): 716-26, 2004.
Sandelin K, Tullgren O, Farnebo LO: Clinical course of metastatic parathyroid cancer. World J Surg 18 (4): 594-8; discussion 599, 1994 Jul-Aug.
Favia G, Lumachi F, Polistina F, et al.: Parathyroid carcinoma: sixteen new cases and suggestions for correct management. World J Surg 22 (12): 1225-30, 1998.