PC-SPES (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Summary of the Evidence for PC-SPES
To assist readers in evaluating the results of human studies of complementary and alternative medicine (CAM) treatments for cancer, the strength of the evidence (i.e., the levels of evidence) associated with each type of treatment is provided whenever possible. To qualify for a level of evidence analysis, a study must:
Be published in a peer-reviewed scientific journal.
Report on therapeutic outcome or outcomes, such as tumor response, improvement in survival, or measured improvement in quality of life.
Describe clinical findings in sufficient detail that a meaningful evaluation can be made.
The lack of consistent composition of PC-SPES due to varying concentrations of adulterants makes it difficult to determine the effects of PC-SPES in humans; therefore, no level of evidence analysis is possible for this treatment. At this time, the use of PC-SPES as a treatment for cancer cannot be recommended outside the context of well-designed clinical trials.
Sedation may be considered for comfort.
Patients with advanced cancer or near the end of life may have:
A lot of emotional distress and physical pain.
Difficult and painful breathing.
Confusion (especially when body systems begin to fail).
Sedation can be given to ease these conditions. This is called palliative sedation. Deciding to use palliative sedation may be difficult for the family as well as the patient. The patient and family can get support from the health care team and...