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Cancer Health Center

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Penile Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage IV Penile Cancer

Stage IV penile cancer is defined by the following TNM classifications:

  • T4, Any N, M0
  • Any T, N3, M0
  • Any T, Any N, M1

No standard treatment exists that is curative for patients with stage IV penile cancer. Therapy is directed at palliation, which may be achieved either with surgery or radiation therapy.

Recommended Related to Cancer

General Information About Pancreatic Cancer

This summary provides information about the treatment of exocrine pancreatic cancer. Other PDQ summaries containing information related to cancer in the pancreas include the following: Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment. Unusual Cancers of Childhood Treatment (pancreatic cancer during childhood). Incidence and Mortality Estimated new cases and deaths from pancreatic cancer in the United States in 2014:[1] New cases: 46,420. Deaths: 39,590...

Read the General Information About Pancreatic Cancer article > >

Standard treatment options:

  1. Palliative surgery may be considered for control of the local penile lesion and even for the prevention of the necrosis, infection, and hemorrhage that can result from neglected regional adenopathy.
  2. Radiation therapy may be palliative for the primary tumor, regional adenopathy, and bone metastases.

Treatment options under clinical evaluation:

  • Clinical trials combining chemotherapy with palliative methods of local control are appropriate for such patients (tested chemotherapeutic drugs with some efficacy include vincristine, cisplatin, methotrexate, and bleomycin). The combination of vincristine, bleomycin, and methotrexate has been effective both as adjuvant and neoadjuvant therapy.[2]

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV penile cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.


  1. Penis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 447-55.
  2. Pizzocaro G, Piva L: Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis. Acta Oncol 27 (6b): 823-4, 1988.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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