This complementary and alternative medicine (CAM) information summary provides an overview of the use of coenzyme Q10 in cancer therapy. The summary includes a history of coenzyme Q10 research, a review of laboratory studies, and data from investigations involving human subjects. Although several naturally occurring forms of coenzyme Q have been identified, Q10 is the predominant form found in humans and most mammals, and it is the form most studied for therapeutic potential. Thus, it will be the...
Added Motzer et al. as reference 30. Revised text to state that the primary endpoint was progression-free survival (PFS), and the data were analyzed when disease in 88% of the axitinib patients and 90% of the sorafenib patients had progressed, while 58% and 59%, respectively, had died.
Revised text to state that median PFS was 8.3 months for axitinib and 5.7 months for sorafenib, and median overall survival (OS) was 20.1 months with axitinib versus 19.2 months with sorafenib; however, the largest benefit was seen in patients who received cytokines as first-line therapy and whose median PFS was 12.2 months with axitinib compared with 8.2 months with sorafenib, while median overall survival was 29.4 months with axitinib compared with 27.8 months with sorafenib. Also added that in contrast, in patients who had previously received sunitinib, axitinib was associated with a 2.1-month increase in PFS compared with sorafenib, but median OS was nearly identical: 15.2 months with axitinib compared with 16.5 months with sorafenib.
Revised text to state that comparing the toxicity of the axitinib and sorafenib regimens is complicated.
Added text to include axitinib on the list of single or combination therapies for which there are ongoing clinical trials to which patients might be directed.
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September 04, 2014
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