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Changes to This Summary (10 / 05 / 2012)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

    General Information

    Recommended Related to Cancer

    Pheochromocytoma During Pregnancy

    Pheochromocytoma diagnosed during pregnancy is extremely rare (0.007% of all pregnancies).[1,2] However, this situation deserves mention because women with hereditary conditions that increase the risk of developing pheochromocytoma are often also of child-bearing age, and the outcome of undiagnosed pheochromocytoma during pregnancy can be catastrophic. Diagnosis Prenatal diagnosis clearly results in decreased mortality for both mother and neonate.[3] Prior to 1970, a prenatal diagnosis of...

    Read the Pheochromocytoma During Pregnancy article > >

    Revised text to state that the RB1 germline mutation may have been inherited from an affected progenitor or may have occurred in utero at the time of conception, in patients with sporadic disease. Also revised text to state that the penetrance of the mutation is probably dependent on concurrent genetic modifiers such as MDM2 and MDM4 (cited de Oliveira et al. as reference 5).

    Added text about how early-in-life screening by fundus exams under general anesthesia at regular intervals can improve prognosis in terms of globe sparing in children with positive family histories of retinoblastoma (cited Rothschild et al. as reference 10).

    The Subsequent neoplasms subsection was renamed from Second malignant neoplasms.

    Revised text to state that more recent studies analyzing cohorts of patients treated with more advanced radiation planning and delivery technology have reported the incidence to be about 9.4% in nonirradiated patients and about 30.4% in irradiated patients.

    Stage Information

    Revised text to state that extraocular retinoblastoma may be confined to the tissues around the eye (orbital retinoblastoma), or it may have spread to the central nervous system, bone marrow, or lymph nodes (metastatic retinoblastoma).

    Intraocular Retinoblastoma Treatment

    This section was extensively revised.

    This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

      WebMD Public Information from the National Cancer Institute

      Last Updated: February 25, 2014
      This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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