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Stage Information

    Before a biopsy of a suspected tumor mass is performed, imaging studies of the mass and baseline laboratory studies should be obtained. After the diagnosis of rhabdomyosarcoma has been made, an extensive evaluation to determine the extent of the disease should be done prior to instituting therapy. This evaluation should include a chest x-ray, computed tomography (CT) scan of the chest, bilateral bone marrow aspirates and biopsies, bone scan, magnetic resonance imaging (MRI) of the base of the skull and brain (for parameningeal primary tumors only), and CT scan of the abdomen and pelvis (for lower extremity or genitourinary primary tumors).

    A CT or MRI scan of regional lymph nodes should be considered. Abnormal-appearing lymph nodes should be biopsied when possible. One study has demonstrated that sentinel lymph node biopsies can be safely performed in children with rhabdomyosarcoma, and tumor-positive biopsies may alter the treatment plan.[1] Positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) scans can identify areas of possible metastatic disease not seen by other imaging modalities.[2,3,4] However, the efficacy of these two procedures for identifying involved lymph nodes or other sites is currently under investigation, and these procedures are not required by current treatment protocols.

    Terms used in this summary section are defined below in Table 1.

    Table 1. Definition of Terms

    TermDefinition
    Favorable siteOrbit; nonparameningeal head and neck; genitourinary tract other than kidney, bladder, and prostate; biliary tract.
    Unfavorable siteAny site other than favorable.
    T1Tumor confined to anatomic site of origin (noninvasive).
    T2Tumor extension and/or fixation to surrounding tissue (invasive).
    aTumor ≤5 cm in maximum diameter.
    bTumor >5 cm in maximum diameter.
    N0No clinical regional lymph node involvement.
    N1Clinical regional lymph node involvement.
    NXRegional lymph nodes not examined; no information.
    M0No metastatic disease.
    M1Metastatic disease.

    Staging of rhabdomyosarcoma is relatively complex. The process includes the following steps:

    1. Assigning a Stage: Determined by primary site, tumor size (widest diameter), and presence or absence of regional lymph node and/or distant metastases.
    2. Assigning a local tumor Group: Determined by status postsurgical resection/biopsy, with pathologic assessment of the tumor margin and of lymph node disease.
    3. Assigning a Risk Group: Determined by Stage, Group, and histology.
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