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Selected Vegetables/Sun's Soup (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

The following information is summarized in a table located at the end of this section.

The use of Selected Vegetables/Sun's Soup as a treatment for human cancer has been investigated in only a limited manner. All available resources—the developer's patent document [1] and the published reports of two clinical studies [2,3]—have identified fewer than 50 treated patients.

As noted previously (refer to the History section of this summary for more information), the developer's patent document describes four patients with advanced cancer who reportedly benefited from treatment with Selected Vegetables/Sun's Soup.[1] Among the four, three patients were said to have had complete tumor regression. However, two of the four patients were treated concurrently with chemotherapy and radiation therapy, and the remaining two were treated with concurrent chemotherapy.[1] Therefore, the actual benefit of Selected Vegetables/Sun's Soup, if any, to these patients is difficult to determine.

In 1992, the developer initiated a phase I/II clinical trial in the Czech Republic to test Selected Vegetables/Sun's Soup as a treatment for non-small cell lung cancer.[2,3] The trial included a "toxicity arm" to assess the tolerability of long-term administration of Selected Vegetables/Sun's Soup and a "survival arm" to assess the mixture's ability to improve survival in patients with advanced disease. Five patients with stage I cancer were included in the toxicity arm; these patients were treated with conventional therapy (surgery plus radiation therapy or radiation therapy alone) in addition to Selected Vegetables/Sun's Soup. Nineteen patients with stage III or stage IV disease were included in the survival arm; six of these patients were treated with conventional therapy (radiation therapy alone or chemotherapy alone) in addition to Selected Vegetables/Sun's Soup, and 13 were treated with conventional therapy (radiation therapy alone, chemotherapy alone, surgery plus radiation therapy, or chemotherapy plus radiation therapy) (12 patients) or best supportive care (one patient) but not Selected Vegetables/Sun's Soup.

The intended duration of Selected Vegetables/Sun's Soup treatment for all patients who received the mixture was 24 months. The intended daily dose was 30 g of freeze-dried powder (i.e., DSV; refer to the General Information section of this summary for more information), mixed with water or other soup. Changes in body weight and changes in Karnofsky Performance Status (KPS) were measured in both arms of the trial. Median survival time was the primary endpoint in the survival arm.

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