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Cancer Health Center

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Skin Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Skin Cancer

Table 4. Distant Metastasis (M) for Non-Eyelid Carcinomaa continued...

Stage III patients are those with either of the following:

  • Clinical, histologic, or radiologic evidence of one involved lymph node measuring 3 cm or less in size.
  • Tumor extension into bone; namely, the maxilla, mandible, orbit, or temporal bone.

Stage IV patients are those with any of the following:

  • Tumor with direct or perineural invasion of skull base or axial skeleton.
  • Two or more involved lymph nodes.
  • Single or multiple involved lymph nodes measuring more than 3 cm in size.
  • Distant metastases.

Table 5. Anatomic Stage/Prognostic Groups for Non-Eyelid Carcinomaa

a Reprinted with permission from AJCC: Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 301-14.
Any TN3M0
T4Any NM0
Any TAny NM1

Staging for Carcinomas of the Eyelid

The AJCC has designated staging by TNM classification.[2] The TNM classification is used to stage all cell types of eyelid carcinomas.

Table 6. Primary Tumor (T) for Eyelid Carcinomaa

a Reprinted with permission from AJCC: Carcinoma of the Eyelid. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 523-6.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
TisCarcinomain situ.
T1Tumor ≤5 mm in greatest dimension.
Not invading the tarsal plate or eyelid margin.
T2aTumor >5 mm but not >10 mm in greatest dimension.
Or, any tumor that invades the tarsal plate or eyelid margin.
T2bTumor >10 mm but not >20 mm in greatest dimension.
Or, involves full thickness eyelid.
T3aTumor >20 mm in greatest dimension.
Or, any tumor that invades adjacent ocular or orbital structures.
Any T with perineural tumor invasion.
T3bComplete tumor resection requires enucleation, exenteration, or bone resection.
T4Tumor is not resectable because of extensive invasion of ocular, orbital, craniofacial structures, or brain.
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