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Skin Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Skin Cancer

Table 4. Distant Metastasis (M) for Non-Eyelid Carcinomaa continued...

Stage III patients are those with either of the following:

  • Clinical, histologic, or radiologic evidence of one involved lymph node measuring 3 cm or less in size.
  • Tumor extension into bone; namely, the maxilla, mandible, orbit, or temporal bone.

Stage IV patients are those with any of the following:

  • Tumor with direct or perineural invasion of skull base or axial skeleton.
  • Two or more involved lymph nodes.
  • Single or multiple involved lymph nodes measuring more than 3 cm in size.
  • Distant metastases.

Table 5. Anatomic Stage/Prognostic Groups for Non-Eyelid Carcinomaa

StageTNM
a Reprinted with permission from AJCC: Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 301-14.
0TisN0M0
IT1N0M0
IIT2N0M0
IIIT3N0M0
T1N1M0
T2N1M0
T3N1M0
IVT1N2M0
T2N2M0
T3N2M0
Any TN3M0
T4Any NM0
Any TAny NM1

Staging for Carcinomas of the Eyelid

The AJCC has designated staging by TNM classification.[2] The TNM classification is used to stage all cell types of eyelid carcinomas.

Table 6. Primary Tumor (T) for Eyelid Carcinomaa

a Reprinted with permission from AJCC: Carcinoma of the Eyelid. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 523-6.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
TisCarcinomain situ.
T1Tumor ≤5 mm in greatest dimension.
Not invading the tarsal plate or eyelid margin.
T2aTumor >5 mm but not >10 mm in greatest dimension.
Or, any tumor that invades the tarsal plate or eyelid margin.
T2bTumor >10 mm but not >20 mm in greatest dimension.
Or, involves full thickness eyelid.
T3aTumor >20 mm in greatest dimension.
Or, any tumor that invades adjacent ocular or orbital structures.
Any T with perineural tumor invasion.
T3bComplete tumor resection requires enucleation, exenteration, or bone resection.
T4Tumor is not resectable because of extensive invasion of ocular, orbital, craniofacial structures, or brain.
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