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    Skin Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Skin Cancer

    Table 4. Distant Metastasis (M) for Non-Eyelid Carcinomaa continued...

    Stage III patients are those with either of the following:

    • Clinical, histologic, or radiologic evidence of one involved lymph node measuring 3 cm or less in size.
    • Tumor extension into bone; namely, the maxilla, mandible, orbit, or temporal bone.

    Stage IV patients are those with any of the following:

    • Tumor with direct or perineural invasion of skull base or axial skeleton.
    • Two or more involved lymph nodes.
    • Single or multiple involved lymph nodes measuring more than 3 cm in size.
    • Distant metastases.

    Table 5. Anatomic Stage/Prognostic Groups for Non-Eyelid Carcinomaa

    Stage T N M
    a Reprinted with permission from AJCC: Cutaneous squamous cell carcinoma and other cutaneous carcinomas. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 301-14.
    0 Tis N0 M0
    I T1 N0 M0
    II T2 N0 M0
    III T3 N0 M0
    T1 N1 M0
    T2 N1 M0
    T3 N1 M0
    IV T1 N2 M0
    T2 N2 M0
    T3 N2 M0
    Any T N3 M0
    T4 Any N M0
    Any T Any N M1

    Staging for Carcinomas of the Eyelid

    The AJCC has designated staging by TNM classification.[2] The TNM classification is used to stage all cell types of eyelid carcinomas.

    Table 6. Primary Tumor (T) for Eyelid Carcinomaa

    a Reprinted with permission from AJCC: Carcinoma of the Eyelid. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 523-6.
    TX Primary tumor cannot be assessed.
    T0 No evidence of primary tumor.
    Tis Carcinomain situ.
    T1 Tumor ≤5 mm in greatest dimension.
    Not invading the tarsal plate or eyelid margin.
    T2a Tumor >5 mm but not >10 mm in greatest dimension.
    Or, any tumor that invades the tarsal plate or eyelid margin.
    T2b Tumor >10 mm but not >20 mm in greatest dimension.
    Or, involves full thickness eyelid.
    T3a Tumor >20 mm in greatest dimension.
    Or, any tumor that invades adjacent ocular or orbital structures.
    Any T with perineural tumor invasion.
    T3b Complete tumor resection requires enucleation, exenteration, or bone resection.
    T4 Tumor is not resectable because of extensive invasion of ocular, orbital, craniofacial structures, or brain.
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