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    Small Intestine Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Small Intestine Cancer

    The treatment sections of this summary are organized according to histopathologic type rather than stage.

    Definitions of TNM

    The American Joint Committee on Cancer (AJCC) has designated staging by TNM classification to define small intestine cancer.[1]

    Table 1. Primary Tumor (T)a

    a Reprinted with permission from AJCC: Small intestine. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 127-32.
    b The nonperitonealized perimuscular tissue is, for jejunum and ileum, part of the mesentery and, for duodenum in areas where serosa is lacking, part of the interface with the pancreas.
    TX Primary tumor cannot be assessed.
    T0 No evidence of primary tumor.
    Tis Carcinoma in situ.
    T1a Tumor invades lamina propria.
    T1b Tumor invades submucosa.b
    T2 Tumor invades muscularis propria.
    T3 Tumor invades through the muscularis propria into the subserosa or into the nonperitonealized perimuscular tissue (mesentery or retroperitoneum) with extension ≤2 cm.b
    T4 Tumor perforates the visceral peritoneum or directly invades other organs or structures (includes other loops of small intestine, mesentery, or retroperitoneum >2 cm, and abdominal wall by way of serosa; for duodenum only, invasion of pancreas or bile duct).

    Table 2. Regional Lymph Nodes (N)a

    a Reprinted with permission from AJCC: Small intestine. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 127-32.
    NX Regional lymph nodes cannot be assessed.
    N0 No regional lymph node metastasis.
    N1 Metastasis in 1-3 regional lymph nodes.
    N2 Metastases in ≥4 regional lymph nodes.

    Table 3. Distant Metastasis (M)a

    a Reprinted with permission from AJCC: Small intestine. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 127-32.
    M0 No distant metastasis.
    M1 Distant metastasis.

    Table 4. Anatomic Stage/Prognostic Groupsa

    Stage T N M
    a Reprinted with permission from AJCC: Small intestine. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 127-32.
    0 Tis N0 M0
    I T1 N0 M0
    T2 N0 M0
    IIA T3 N0 M0
    IIB T4 N0 M0
    IIIA Any T N1 M0
    IIIB Any T N2 M0
    IV Any T Any N M1

    References:

    1. Small intestine. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 127-32.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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