Gastrointestinal stromal tumor is a disease in which abnormal cells form in the tissues of the gastrointestinal tract.
The gastrointestinal (GI) tract is part of the body's digestive system. It helps to digest food and takes nutrients (vitamins, minerals, carbohydrates, fats, proteins, and water) from food so they can be used by the body. The GI tract is made up of the following organs:
Large intestine (colon).
Gastrointestinal stromal tumors (GISTs) may be...
External Validity: Poor. Studies on populations in high-risk areas may not be applicable to low-risk areas such as the United States.
Based on solid evidence, screening would result in uncommon but serious side effects associated with endoscopy, which may include perforation, cardiopulmonary events, aspiration pneumonia, and bleeding requiring hospitalization.
False-positive tests are also common in association with serum pepsinogen or gastric photofluorography.
Magnitude of Effect: Good evidence for rare but serious harms.
Description of the Evidence
Study Design: Evidence obtained from screening programs and from case series.
Internal Validity: Fair.
Consistency: Inadequate evidence.
External Validity: Poor.
Leung WK, Wu MS, Kakugawa Y, et al.: Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol 9 (3): 279-87, 2008.
WebMD Public Information from the National Cancer Institute
September 04, 2014
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