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Cancer Health Center

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Testicular Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Testicular Cancer

Table 3. Distant Metastasis (M)a

a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
M0 No distant metastasis.
M1 Distant metastasis.
M1a Nonregional nodal or pulmonary metastasis.
M1b Distant metastasis other than to nonregional lymph nodes and lung.

Table 4. Anatomic Stage/Prognostic Groupsa

Group T N M S (Serum Tumor Markers)
a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
0 pTis N0 M0 S0
I pT1-4 N0 M0 SX
IA pT1 N0 M0 S0
IB pT2 N0 M0 S0
pT3 N0 M0 S0
pT4 N0 M0 S0
IS Any pT/Tx N0 M0 S1-3
II Any pT/Tx N1-3 M0 SX
IIA Any pT/Tx N1 M0 S0
Any pT/Tx N1 M0 S1
IIB Any pT/Tx N2 M0 S0
Any pT/Tx N2 M0 S1
IIC Any pT/Tx N3 M0 S0
Any pT/Tx N3 M0 S1
III Any pT/Tx Any N M1 SX
IIIA Any pT/Tx Any N M1a S0
Any pT/Tx Any N M1a S1
IIIB Any pT/Tx N1-3 M0 S2
Any pT/Tx Any N M1a S2
IIIC Any pT/Tx N1-3 M0 S3
Any pT/Tx Any N M1a S3
Any pT/Tx Any N M1b Any S

Table 5. Site-Specific Prognostic Factorsa

Serum Tumor Markers (S) Required for Staging
AFP = alpha-fetoprotein; hCG = human chorionic gonadotropin; LDH = lactase dehydrogenase; N indicates the upper limit of normal for the LDH assay.
a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
SX Marker studies not available or not performed.
S0 Marker study levels within normal limits.
S1 LDH <1.5 × Nband hCG (mIu/ml) <5,000and AFP (ng/ml) <1,000.
S2 LDH 1.5-10 × Nor hCG (mIu/ml) 5,000-50,000or AFP (ng/ml) 1,000-10,000.
S3 LDH >10 × Nor hCG (mIu/ml) >50,000or AFP (ng/ml) >10,000.
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