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    Testicular Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Testicular Cancer

    Table 3. Distant Metastasis (M)a

    a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
    M0 No distant metastasis.
    M1 Distant metastasis.
    M1a Nonregional nodal or pulmonary metastasis.
    M1b Distant metastasis other than to nonregional lymph nodes and lung.

    Table 4. Anatomic Stage/Prognostic Groupsa

    Group T N M S (Serum Tumor Markers)
    a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
    0 pTis N0 M0 S0
    I pT1-4 N0 M0 SX
    IA pT1 N0 M0 S0
    IB pT2 N0 M0 S0
    pT3 N0 M0 S0
    pT4 N0 M0 S0
    IS Any pT/Tx N0 M0 S1-3
    II Any pT/Tx N1-3 M0 SX
    IIA Any pT/Tx N1 M0 S0
    Any pT/Tx N1 M0 S1
    IIB Any pT/Tx N2 M0 S0
    Any pT/Tx N2 M0 S1
    IIC Any pT/Tx N3 M0 S0
    Any pT/Tx N3 M0 S1
    III Any pT/Tx Any N M1 SX
    IIIA Any pT/Tx Any N M1a S0
    Any pT/Tx Any N M1a S1
    IIIB Any pT/Tx N1-3 M0 S2
    Any pT/Tx Any N M1a S2
    IIIC Any pT/Tx N1-3 M0 S3
    Any pT/Tx Any N M1a S3
    Any pT/Tx Any N M1b Any S

    Table 5. Site-Specific Prognostic Factorsa

    Serum Tumor Markers (S) Required for Staging
    AFP = alpha-fetoprotein; hCG = human chorionic gonadotropin; LDH = lactase dehydrogenase; N indicates the upper limit of normal for the LDH assay.
    a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
    SX Marker studies not available or not performed.
    S0 Marker study levels within normal limits.
    S1 LDH <1.5 × Nband hCG (mIu/ml) <5,000and AFP (ng/ml) <1,000.
    S2 LDH 1.5-10 × Nor hCG (mIu/ml) 5,000-50,000or AFP (ng/ml) 1,000-10,000.
    S3 LDH >10 × Nor hCG (mIu/ml) >50,000or AFP (ng/ml) >10,000.
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