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Testicular Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Testicular Cancer

Table 3. Distant Metastasis (M)a

a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
M0No distant metastasis.
M1Distant metastasis.
M1aNonregional nodal or pulmonary metastasis.
M1bDistant metastasis other than to nonregional lymph nodes and lung.

Table 4. Anatomic Stage/Prognostic Groupsa

GroupTNMS (Serum Tumor Markers)
a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
0pTisN0M0S0
IpT1–4N0M0SX
IApT1N0M0S0
IBpT2N0M0S0
pT3N0M0S0
pT4N0M0S0
ISAny pT/TxN0M0S1–3
IIAny pT/TxN1–3M0SX
IIAAny pT/TxN1M0S0
Any pT/TxN1M0S1
IIBAny pT/TxN2M0S0
Any pT/TxN2M0S1
IICAny pT/TxN3M0S0
Any pT/TxN3M0S1
IIIAny pT/TxAny NM1SX
IIIAAny pT/TxAny NM1aS0
Any pT/TxAny NM1aS1
IIIBAny pT/TxN1–3M0S2
Any pT/TxAny NM1aS2
IIICAny pT/TxN1–3M0S3
Any pT/TxAny NM1aS3
Any pT/TxAny NM1bAny S

Table 5. Site-Specific Prognostic Factorsa

Serum Tumor Markers (S) Required for Staging
AFP = alpha-fetoprotein; hCG = human chorionic gonadotropin; LDH = lactase dehydrogenase; N indicates the upper limit of normal for the LDH assay.
a Reprinted with permission from AJCC: Testis. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 469-78.
SXMarker studies not available or not performed.
S0Marker study levels within normal limits.
S1LDH <1.5 × Nband hCG (mIu/ml) <5,000and AFP (ng/ml) <1,000.
S2LDH 1.5–10 × Nor hCG (mIu/ml) 5,000–50,000or AFP (ng/ml) 1,000–10,000.
S3LDH >10 × Nor hCG (mIu/ml) >50,000or AFP (ng/ml) >10,000.
1|2|3|4
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