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Testicular Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview

There are different types of treatment for patients with testicular cancer.

Different types of treatments are available for patients with testicular cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.

Testicular tumors are divided into 3 groups, based on how well the tumors are expected to respond to treatment.

Good Prognosis

For nonseminoma, all of the following must be true:

  • The tumor is found only in the testicle or in the retroperitoneum (area outside or behind the abdominal wall); and
  • The tumor has not spread to organs other than the lungs; and
  • The levels of all the tumor markers are slightly above normal.

For seminoma, all of the following must be true:

  • The tumor has not spread to organs other than the lungs; and
  • The level of alpha-fetoprotein (AFP) is normal. Beta-human chorionic gonadotropin (β-hCG) and lactate dehydrogenase (LDH) may be at any level.

Intermediate Prognosis

For nonseminoma, all of the following must be true:

  • The tumor is found in one testicle only or in the retroperitoneum (area outside or behind the abdominal wall); and
  • The tumor has not spread to organs other than the lungs; and
  • The level of any one of the tumor markers is more than slightly above normal.

For seminoma, all of the following must be true:

  • The tumor has spread to organs other than the lungs; and
  • The level of AFP is normal. β-hCG and LDH may be at any level.

Poor Prognosis

For nonseminoma, at least one of the following must be true:

  • The tumor is in the center of the chest between the lungs; or
  • The tumor has spread to organs other than the lungs; or
  • The level of any one of the tumor markers is high.
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