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Unusual Cancers of Childhood Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Other Rare Childhood Cancers

Table 8. Characteristics of Melanocytic Lesions continued...

Diagnostic evaluation

For all patients who present with tumors from an unknown primary site, treatment should be directed toward the specific histopathology of the tumor and should be age-appropriate for the general type of cancer initiated, irrespective of the site or sites of involvement.[146] Studies in adults suggest that positron emission tomography (PET) imaging can be helpful in identifying cancers of unknown primary site, particularly in patients whose tumors arise in the head and neck area.[148] A report in adults using fludeoxyglucose (FDG) PET-CT identified 42.5% of primary tumors in a group of cancers of unknown primary site.[149] In addition, molecular assignment of tissue of origin using molecular profiling techniques is feasible and can aid in identifying the putative tissue of origin in about 60% of patients with cancers of unknown primary site.[150] It is still unclear, however, whether these techniques can improve the outcomes or response rates of these patients, and no pediatric studies have been conducted.[151]

Treatment

Chemotherapy and radiation therapy treatments appropriate and relevant for the general category of carcinoma or sarcoma (depending on the histologic findings, symptoms, and extent of tumor) should be initiated as early as possible.

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Last Updated: February 25, 2014
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