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    Unusual Cancers of Childhood Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Abdominal Cancers


    Survival is consistent with the advanced stage of disease observed in most children with colorectal cancer, with an overall mortality rate of approximately 70%. For patients with a complete surgical resection or for those with low-stage/localized disease, survival is significantly prolonged, with curative potential.[80]

    Genetic syndromes associated with colorectal cancer

    About 20% to 30% of adult patients with colorectal cancer have a significant history of familial cancer; of these, about 5% have a well-defined genetic syndrome.[99] The incidence of these syndromes in children has not been well defined. In one review, 16% of patients younger than 40 years had a predisposing factor for the development of colorectal cancer.[100] A later study documented immunohistochemical evidence of mismatch repair deficiency in 31% of colorectal carcinoma samples in patients aged 30 years or younger.[101] The most common genetic syndromes associated with the development of colorectal cancer are shown in Tables 3 and 4.

    Table 3. Common Genetic Syndromes Associated With Adenomatous Polyposis

    Syndrome Gene Gene Function Hereditary Pattern
    Attenuated familial adenomatous polyposis APC(5' mutations),AXIN2 Tumor suppressor Dominant
    Familial adenomatous polyposis (Gardner syndrome) APC Tumor suppressor Dominant
    Lynch syndrome (hereditary nonpolyposis colorectal cancer) MSH2, MLH1, MSH6, PMS2, EPCAM Repair/stability Dominant
    Li-Fraumeni syndrome TP53(p53) Tumor suppressor Dominant
    MYH-associated polyposis MYH(MUTYH) Repair/stability Recessive
    Turcot syndrome APC Tumor suppressor Dominant
    MLH1 Repair/stability Dominant

    Table 4. Common Genetic Syndromes Associated With Hamartomatous Polyps

    Syndrome Gene Gene Function Hereditary Pattern
    Cowden syndrome PTEN Tumor suppressor Dominant
    Juvenile polyposis syndrome BMPR1A, SMAD4, ENG Tumor suppressor Dominant
    Peutz-Jeghers syndrome STK11 Tumor suppressor Dominant

    Familial polyposis is inherited as a dominant trait, which confers a high degree of risk. Early diagnosis and surgical removal of the colon eliminates the risk of developing carcinomas of the large bowel.[102] Some colorectal carcinomas in young people, however, may be associated with a mutation of the adenomatous polyposis coli (APC) gene, which also is associated with an increased risk of brain tumors and hepatoblastoma.[103] The familial APC syndrome is caused by mutation of a gene on chromosome 5q, which normally suppresses proliferation of cells lining the intestine and later development of polyps.[104] A double-blind, placebo-controlled, randomized phase I trial in children aged 10 to 14 years with familial adenomatous polyposis (FAP) reported that celecoxib at a dose of 16 mg/kg/day is safe for administration for up to 3 months. At this dose, there was a significant decrease in the number of polyps detected on colonoscopy.[105][Level of evidence: 1iiDiv] The role of celecoxib in the management of FAP is not known.

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