Squamous Cell Carcinoma

STANDARD TREATMENT OPTIONS:

1. Combination of interstitial, intracavitary, and external-beam radiation therapy (EBRT).[1]
2. Rarely, surgery may be combined with the above.[2]

Adenocarcinoma

STANDARD TREATMENT OPTIONS:

1. Combination of interstitial, intracavitary, and EBRT.[1]
2. Rarely, surgery may be combined with the above.

Current Clinical Trials

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage IVA vaginal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

References:

1. Perez CA, Camel HM, Galakatos AE, et al.: Definitive irradiation in carcinoma of the vagina: long-term evaluation of results. Int J Radiat Oncol Biol Phys 15 (6): 1283-90, 1988.
2. Boronow RC, Hickman BT, Reagan MT, et al.: Combined therapy as an alternative to exenteration for locally advanced vulvovaginal cancer. II. Results, complications, and dosimetric and surgical considerations. Am J Clin Oncol 10 (2): 171-81, 1987.