For patients with suspected Wilms tumors, preoperative staging studies should include a computed tomography (CT) scan of the abdomen/pelvis and chest. Preoperative assessment of intravascular extension of Wilms tumor is essential to guide management. The presence of intravenous tumor thrombus, which has been reported in up to 11.3% of Wilms tumor cases, can lead to differences in management. In North America, local staging of Wilms tumor is performed with CT or magnetic resonance imaging of the abdomen and pelvis. Contrast-enhanced CT has high sensitivity and specificity for detection of cavoatrial tumor thrombus in Wilms tumor cases that may impact surgical approach. Routine Doppler evaluation after CT has been performed is not required.
The main ingredient of 714-X is camphor, which comes from the wood and bark of the camphor tree (see Question 1).
It is claimed that 714-X helps the immune system fight cancer (see Question 3).
No study of 714-X has been published in a peer-reviewed scientific journal to show it is safe or effective in treating cancer (see Question 6).
714-X is not approved by the US Food and Drug Administration for use in the United States (see Question 8).
The stage is determined by the results of the imaging studies and both the surgical and pathologic findings at nephrectomy and is the same for tumors with favorable or anaplastic histology. Thus, patients should be characterized by a statement of both criteria (for example, stage II, favorable histology or stage II, anaplastic histology).[2,3]
The staging system was originally developed by the National Wilms Tumor Study Group and still used by the Children's Oncology group. The staging system and incidence by stage are outlined below.
In stage I Wilms tumor (43% of patients), all of the following criteria must be met:
Tumor is limited to the kidney and is completely resected.
The renal capsule is intact.
The tumor is not ruptured or biopsied prior to removal.
No evidence of the tumor at or beyond the margins of resection.
For a tumor to qualify for certain therapeutic protocols as stage I, regional lymph nodes must be examined microscopically.
In stage II Wilms tumor (20% of patients), the tumor is completely resected, and there is no evidence of tumor at or beyond the margins of resection. The tumor extends beyond the kidney as evidenced by any one of the following criteria:
There is regional extension of the tumor (i.e., penetration of the renal sinus capsule, or extensive invasion of the soft tissue of the renal sinus, as discussed below).
Blood vessels within the nephrectomy specimen outside the renal parenchyma, including those of the renal sinus, contain tumor.