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Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Wilms Tumor and Other Childhood Kidney Tumors

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Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV Wilms tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage V Wilms Tumor and those at high risk of developing Wilms tumor

Treatment of stage V Wilms tumor may be different for each patient and may include:

  • Combination chemotherapy to shrink the tumor, followed by repeat imaging at 4 to 8 weeks to guide the choice of further therapy (partial nephrectomy, biopsy, continued chemotherapy, and/or radiation therapy).
  • A biopsy of the kidneys is followed by chemotherapy to shrink the tumor. Second-look surgery is done to remove as much of the cancer as possible. This may be followed by more chemotherapy and/or radiation therapy if cancer remains after surgery.
  • A clinical trial of chemotherapy to shrink the tumor, followed by repeat imaging at 6 and 12 weeks to guide the choice of further therapy (surgery, biopsy, continued chemotherapy and/or radiation therapy).

If a kidney transplant is needed because of kidney problems, it is delayed until 1 to 2 years after treatment is completed and there are no signs of cancer.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage V Wilms tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Inoperable Tumors

Sometimes the tumor is inoperable (cannot be removed by surgery) because it is too close to important organs or blood vessels, too large to remove, or there is cancer in both kidneys. In this case, chemotherapy may be given to reduce the size of the tumor so as much tumor as possible can be removed in surgery. Radiation therapy is given after surgery.

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