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Brain Tumor Surgery Dye

Reviewed By: Louise Chang,

SOURCES: This Video is from the WebMD Video Archive. Medical Reference from Medstar Television. www.medstar.com For information about TRISENOX® (arsenic trioxide), http://www.cticseattle.com/products_pinfo.htm The American Cancer Society, http://www.cancer.org

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Dr. Ruge and Samantha:

So how are you doing? Good! Do you mind if I test your reflexes? Sure!

Narrator:

Nine-year-old Samantha Gadomski (guh DOMM skee) has quick reflexes. A good sign just a few months after surgery to remove a brain tumor.

Christine Gadomski:

They didn't want it to grow bigger. So needless to say, we had surgery within six days of finding out that she had a tumor.

Narrator:

To help find it all, Samantha's tumor was illumied by an investigational dye called 5-ALA.

John Ruge, M.D.:

Our body already has 5-ALA, as we call it, in it. We're just providing an additional amount that we, fortuitously, some malignant tumors take up in excess.

Narrator:

Patients drink the dye a few hours before surgery, giving the tumor time to absorb it.

John Ruge, M.D.:

We try to time our surgery where we would be in the midst of the, when we really need it, about six hours from the time of ingestion.

Narrator:

When exposed to blue-violet light, the dye glows, alerting doctors to rogue tissue that needs to come out.

John Ruge, M.D.:

Lo and behold, there are some areas that are glowing sometimes, and that, and that leads for more aggressive resection.

Narrator:

In Samantha's case, it helped find a hidden piece of the tumor.

John Ruge, M.D.:

I fluoresced the tumor bed and there was a charcoal glowing in the corner. And I biopsied that, sent it to pathology, and sure enough, it was a malignant tumor.

Narrator:

Because healthy brain tissue wasn't harmed, Samantha's still able to handle the demands of fourth grade.

Samantha Gadomski:

Very hard and a lot of homework.

Narrator:

Helping Samantha and her family take the next steps in her recovery. For WebMD, I'm Damon Meharg.

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