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Bladder Cancer in Men

Reviewed By: Varnada Karriem-Norwood,

SOURCES: 2008 Medical Reference from Medstar. Edward Messing, MD, FACS, Urologist, University of Rochester Medical Center, Rochester, NY.

© 1999-2011 Medstar Television

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Narrator:

When Randy Hunter noticed blood in his urine, he did what many men do: he put-off calling the doctor.

Randy Hunter, Bladder Cancer Survivor:

I was the pig-headed male you know, and also I was sort of nervous and scared about going to the doctors.

Narrator:

At the time, Randy was just 42, had no risk factors, yet was diagnosed with bladder cancer.

Randy Hunter, Bladder Cancer Survivor:

Every time I have to catheterize myself, yes I did have cancer even though I feel great. And, but it's just… I'm reminded.

Narrator:

Men develop bladder cancer at four times the rate of women. Looking at what triggers it is the focus of research at the Universityof Rochester Medical Center.

Edward Messing, MC, FACS, Urologist, University of Rochester Medical Center:

There are growth factors, hormones like insulin, and sex hormones, that are excreted in the urine in gigantic concentrations.

Narrator:

In their studies, testosterone fueled the growth of bladder cancer in male mice.

Edward Messing, MC, FACS, Urologist, University of Rochester Medical Center:

Stimulates bladder cancer development, while female hormones, it's not clear if it's estrogen or progesterone, or which, tend to be protective.

Narrator:

Genetically "turning off" the receptor for testosterone also reduced risk. The next step is determining whether drugs that block testosterone or its receptor could treat, or prevent, the disease.

Edward Messing, MC, FACS, Urologist, University of Rochester Medical Center:

I wouldn't go so far as to say that we know if they're going to work or not, but certainly, it immediately opens up that possibility.

Narrator:

A possibility that could help more men avoid the diagnosis of bladder cancer. For WebMD, I'm Damon Meharg.

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