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    What Is Anal Cancer?

    Anal cancer is an uncommon malignancy that starts in the anus -- the opening at the end of the rectum.

    The American Cancer Society estimates that 7,210 cases of anal cancer will be diagnosed in 2014 and about 950 deaths will occur that year from anal cancer.

    By contrast, some136,830 people are predicted to be diagnosed with colorectal cancer in the U.S. in 2014, and about 50,310 people are predicted to die of the disease that year.

    Approximately half of all anal cancers are diagnosed before the malignancy has spread beyond the primary site, whereas 13% to 25% are diagnosed after the cancer has spread to the lymph nodes, and 10% are diagnosed after the cancer has spread to distant organs, or has metastasized.

    When it is found early, anal cancer is highly treatable.

    The overall five-year survival rate following diagnosis of anal cancer is 60% for men and 71% for women.

    When the cancer is diagnosed in its earliest stage, five-year survival rate is 82%. Once the cancer has spread to surrounding lymph nodes, the five-year survival drops to 60%. If the cancer has spread to distant organs, about one in five patients lives for five years or more.

    Who Gets Anal Cancer?

    Most anal cancers (80%) are diagnosed in people who are over age 60. Prior to age 35, anal cancer is more common in men. However, after age 50, anal cancer is slightly more common in women.

    The incidence rate of anal cancer is six times higher in single men as compared to married men.

    Receptive anal intercourse is strongly related to the development of anal cancer.

    Anal infection with human papillomavirus (HPV) resulting in genital warts is a major risk factor for the cancer.

    Immunocompromised patients, such as those with HIV disease, are prone to get anal cancer. In this subgroup, the prognosis is worse, than for non-immunocompromised patients.

    Gardasil, one of the HPV vaccines originally approved for the prevention of cervical cancer, is also approved for the prevention of anal cancer in men and women.

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