Skip to content

    Children's Health

    Font Size
    A
    A
    A

    Agammaglobulinemia

    Important
    It is possible that the main title of the report Agammaglobulinemia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • hypogammaglobulinemia

    Disorder Subdivisions

    • X-linked agammaglobulinemia (XLA)
    • X-linked agammaglobulinemia with growth hormone deficiency
    • autosomal recessive agammaglobulinemia

    General Discussion

    Agammaglobulinemia is a group of inherited immune deficiencies characterized by a low concentration of antibodies in the blood due to the lack of particular lymphocytes in the blood and lymph. Antibodies are proteins (immunoglobulins, (IgM), (IgG) etc) that are critical and key components of the immune system. They are essential if the immune system is to do its job of fighting off bacteria, viruses, and other foreign substances that threaten the body. The specialized precursor cells that produce gammaglobulins, fail to develop or function properly leading to the deficiency in the number of mature lymphocyte cells called B cells.

    The types of agammaglobulinemia are: X-linked agammaglobulinemia (XLA), the much rarer X-linked agammaglobulinemia with growth hormone deficiency (about 10 cases reported), and autosomal recessive agammaglobulinemia (ARAG). All of these disorders are characterized by a weakened immune system that must be strengthened by the administration of gammaglobulin in order to fight off infections.

    Resources

    March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains, NY 10605
    Tel: (914)997-4488
    Fax: (914)997-4763
    Tel: (888)663-4637
    Email: Askus@marchofdimes.com
    Internet: http://www.marchofdimes.com

    Immune Deficiency Foundation
    40 W. Chesapeake Avenue
    Suite 308
    Towson, MD 21204
    Tel: (410)321-6647
    Fax: (410)321-9165
    Tel: (800)296-4433
    Email: idf@primaryimmune.org
    Internet: http://www.primaryimmune.org

    Centers for Disease Control and Prevention
    1600 Clifton Road NE
    Atlanta, GA 30333
    Tel: (404)639-3534
    Tel: (800)232-4636
    TDD: (888)232-6348
    Email: cdcinfo@cdc.gov
    Internet: http://www.cdc.gov/

    NIH/National Institute of Allergy and Infectious Diseases
    Office of Communications and Government Relations
    6610 Rockledge Drive, MSC 6612
    Bethesda, MD 20892-6612
    Tel: (301)496-5717
    Fax: (301)402-3573
    Tel: (866)284-4107
    TDD: (800)877-8339
    Email: ocpostoffice@niaid.nih.gov
    Internet: http://www.niaid.nih.gov/

    American Academy of Allergy, Asthma and Immunology
    611 East Wells Street
    Milwaukee, WI 53202
    Tel: (414)272-6071
    Fax: (414)276-3349
    Tel: (800)822-2762
    Email: info@aaaai.org
    Internet: http://www.aaaai.org

    International Patient Organization for Primary Immunodeficiencies
    Firside Main Road
    Downderry
    Cornwall, PL11 3LE
    United Kingdom
    Tel: 441503250668
    Fax: 441503250961
    Email: info@ipopi.org
    Internet: http://www.ipopi.org/

    Jeffrey Modell Foundation
    780 Third Avenue
    New York, NY 10017
    USA
    Tel: (212)819-0200
    Fax: (212)764-4180
    Tel: (866)469-6474
    Email: info@jmfworld.org
    Internet: http://www.info4pi.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Autoimmune Information Network, Inc.
    PO Box 4121
    Brick, NJ 08723
    Fax: (732)543-7285
    Email: autoimmunehelp@aol.com

    European Society for Immunodeficiencies
    1-3 rue de Chantepoulet
    Geneva, CH 1211
    Switzerland
    Tel: 410229080484
    Fax: 41229069140
    Email: esid@kenes.com
    Internet: http://www.esid.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 6/16/2010
    Copyright 1986, 1987, 1988, 1989, 1993, 1996, 1998, 1999, 2001, 2007, 2009, 2010 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

    Today on WebMD

    child with red rash on cheeks
    What’s that rash?
    plate of fruit and veggies
    How healthy is your child’s diet?
     
    smiling baby
    Treating diarrhea, fever and more.
    Middle school band practice
    Understanding your child’s changing body.
     

    worried kid
    fitArticle
    jennifer aniston
    Slideshow
     
    Measles virus
    Article
    sick child
    Slideshow
     

    babyapp
    New
    Child with adhd
    Slideshow
     
    rl with friends
    fitSlideshow
    Child Coughing or Sneezing into Elbow
    Article