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    Fetal Valproate Syndrome

    It is possible that the main title of the report Fetal Valproate Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


    • Dalpro, Fetal Effects From
    • Depakene, Fetal Effects From
    • Depakote Sprinkle, Fetal Effects From
    • Depakote, Fetal Effects From
    • Divalproex, Fetal Effects From
    • Epival, Fetal Effects From
    • Myproic Acid, Fetal Effects From
    • Valproic Acid, Fetal Effects From
    • Fetal Anti-Convulsive Syndrome

    Disorder Subdivisions

    • None

    General Discussion

    Fetal Valproate Syndrome is a rare congenital disorder caused by exposure of the fetus to valproic acid (dalpro, depakene, depakote, depakote sprinkle, divalproex, epival, myproic acid) during the first three months of pregnancy. Valproic acid is an anticonvulsant drug used to control certain types of seizures in the treatment of epilepsy. A small percentage of pregnant women who take this medication can have a child with Fetal Valproate Syndrome. The exact prevalence of this condition remains to be established. Symptoms of this disorder may include spina bifida, distinctive facial features, and other musculoskeletal abnormalities.


    Spina Bifida Association of America
    4590 MacArthur Boulevard NW
    Suite 250
    Washington, DC 20007-4226
    Tel: (202)944-3285
    Fax: (202)944-3295
    Tel: (800)621-3141

    International Federation for Spina Bifida and Hydrocephalus
    Cellebroersstraat 16
    Brussels, B1000
    Tel: 32025020413
    Fax: 32025021129

    Spina Bifida and Hydrocephalus Canada
    Suite 647-167 av. Lombard Avenue
    R3B 0V3
    Tel: 2049253650
    Fax: 2049253654
    Tel: 8005659488

    Organisation For Anti-Convulsant Syndrome
    131 Summertrees Road
    Ellesmere Port
    Cheshire, CH66 2BE
    United Kingdom
    Tel: 01513565949

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

    Last Updated: 4/25/2008
    Copyright 1994, 2003 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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