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    Factor XII Deficiency

    Important
    It is possible that the main title of the report Factor XII Deficiency is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • F12 deficiency
    • HAF deficiency
    • Hageman factor deficiency
    • Hageman trait

    Disorder Subdivisions

    • None

    General Discussion

    Summary
    Factor XII deficiency is a rare genetic blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the factor XII (Hageman factor), a plasma protein (glycoprotein). Specifically, factor XII is a clotting factor. Clotting factors are specialized proteins that are essential for proper clotting, the process by which blood clumps together to plug the site of a wound to stop bleeding. Although it is thought that factor XII is needed for proper blood clotting, when it is deficient, other blood clotting factors appear to compensate for its absence. Therefore, the disorder is thought to be benign and usually presents no symptoms (asymptomatic); it is usually only accidentally discovered through pre-operative blood tests that are required by hospitals.

    Introduction
    Factor XII deficiency was first described in the medical literature in 1955 by doctors Oscar Ratnoff and Jane Colopy in a patient named John Hageman. The disorder is sometimes known as Hageman factor deficiency or Hageman trait.

    Resources

    National Hemophilia Foundation
    116 West 32nd Street, 11th Floor
    New York, NY 10001
    USA
    Tel: (212)328-3700
    Fax: (212)328-3777
    Tel: (800)424-2634
    Email: handi@hemophilia.org
    Internet: http://www.hemophilia.org

    Canadian Hemophilia Society
    400-1255 University Street
    Montreal
    Quebec, H3B 3B6
    Canada
    Tel: 5148480503
    Fax: 5148489661
    Tel: 8006682686
    Email: chs@hemophilia.ca
    Internet: http://www.hemophilia.ca

    NIH/National Heart, Lung and Blood Institute
    P.O. Box 30105
    Bethesda, MD 20892-0105
    Tel: (301)592-8573
    Fax: (301)251-1223
    Email: nhlbiinfo@rover.nhlbi.nih.gov
    Internet: http://www.nhlbi.nih.gov/

    World Federation of Hemophilia
    1425 René Lévesque Blvd. W. Suite 1010
    Montreal
    Quebec, H3G 1T7
    Canada
    Tel: 5148757944
    Fax: 5148758916
    Email: wfh@wfh.org
    Internet: http://www.wfh.org/index.asp?lang=EN

    Hemophilia Federation of America
    210 7th St. SE
    Suite 200B
    Washington, DC 20003
    USA
    Tel: (202)675-6984
    Fax: (202)675-6983
    Tel: (800)230-9797
    Email: info@hemophiliafed.org
    Internet: http://www.hemophiliafed.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Irish Haemophilia Society
    First Floor
    Cathedral Court
    New Street
    Dublin, 7
    Ireland
    Tel: 353016579900
    Fax: 353016579901
    Email: info@haemophilia.ie
    Internet: http://www.haemophilia.ie/

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 5/25/2012
    Copyright 1988, 1989, 2002, 2008, 2012 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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