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Children's Health

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Lung Transplantation May Extend Lives in Children With Cystic Fibrosis

WebMD Health News

Nov. 10, 1999 (Atlanta) -- A new study from London may offer some hope to terminally ill children with respiratory illnesses such as cystic fibrosis (CF).

"We have confirmed that even with the current poor survival after lung transplantation, the procedure still provides an increase in life expectancy for the majority of children," British physician Paul Aurora tells WebMD.

Aurora, a specialist in pediatric respiratory medicine at the Royal Brompton Hospital in London, says that the findings in this new study are consistent with three earlier studies which focused on adults receiving lung transplants.

When compared to other organs, transplanting lungs has been much less successful. Commonly accepted figures for survival rates worldwide for lung transplantation are about 70% one year after the transplant and 45% after four years. Most of these deaths are due to infections and rejection of the organs.

In the study, reported in the November issue of The Lancet, Aurora and colleagues examined the effect of lung or heart-lung transplantation on the survival of 124 children with cystic fibrosis and severe lung disease. Children were accepted for transplantation if they had a life expectancy of two years or less, a poor quality of life, and no factors that would rule out transplantation.

Of the total, nearly 50 children received transplants, nearly 70 died while they awaited organs, and nine remained on the active waiting list. Of the children receiving transplants, 90% received heart-lung transplants, four received a double lung transplant, and one received a single lung transplant. The average waiting time for organs was just over six months. After one year, almost 75% of those receiving transplants were still alive. After five years, approximately one-third of the patients were still alive.

According to the Cystic Fibrosis Foundation, CF is a genetic disease affecting approximately 30,000 children and adults in the United States. It causes the body to produce an abnormally thick, sticky mucus due to the faulty transport of sodium and chloride within cells lining organs, such as the lungs and pancreas, to their outer surfaces. The thick CF mucus not only causes an excessive amount of thick secretions in the airway, but it also blocks the release of pancreatic enzymes which aid in the process of food breakdown and digestion in the intestines. Many organs of the body are adversely affected by cystic fibrosis.

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