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    IVF Conception Doesn't Seem to Raise Kids' Cancer Risk: Study

    British researchers followed more than 100,000 children for 17 years

    WebMD News from HealthDay

    By Steven Reinberg

    HealthDay Reporter

    WEDNESDAY, Nov. 6 (HealthDay News) -- In a reassuring new finding, there appears to be no extra cancer risk among children born after assisted conception.

    More than 5 million children worldwide have been born through in vitro fertilization (IVF). However, concerns that the manipulation of sperm and egg might make these children more prone to cancer prompted the British researchers to investigate.

    However, the risk to IVF-conceived children was found to be "the same as naturally conceived children," said lead researcher Dr. Alastair Sutcliffe, a specialist in general pediatrics at the University College London. "This is a promising sign for their future health as they grow into adult life," he said.

    "[This study, which is] bigger than all the existing studies, has a powerful and reassuring message to families, fertility specialists and the public," Sutcliffe added. "Namely that in a near 100 percent coverage of 106,000 children conceived with IVF, the rate of childhood cancer was almost identical to that of the naturally conceived children over the same time frame."

    Although the overall risk of cancer did not rise for these children, the incidence of two less common types of cancer was higher than expected.

    A U.S expert was pleased with the findings, which were published Nov. 7 in the New England Journal of Medicine.

    "This study is extremely reassuring and should relieve anybody's anxiety about IVF," said Dr. Lawrence Grunfeld, an associate clinical professor of obstetrics, gynecology and reproductive science at the Mount Sinai Icahn School of Medicine, in New York City.

    Studies have found that most medical problems of children conceived through IVF are not a result of the procedure, but can be traced to a genetic risk for a disease or the underlying problem that caused the parent's infertility in the first place, Grunfeld said.

    For the study, Sutcliffe's team collected data on more than 106,000 children born through assisted reproduction between 1992 and 2008. They then compared the number of those children who had cancer with the expected number of cancers among children in the general population before age 15.

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