Skip to content

    Children's Health

    Font Size
    A
    A
    A

    Trisomy X

    Important
    It is possible that the main title of the report Trisomy X is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • 47, XXX
    • 47, XXX karyotype
    • 47, XXX syndrome
    • triple X syndrome
    • triplo X
    • XXX syndrome

    Disorder Subdivisions

    • None

    General Discussion

    Trisomy X is a disorder that affects females and is characterized by the presence of an additional X chromosome. Normally, females have two X chromosomes; however, females with trisomy X carry three X chromosomes in the nuclei of body cells. There are specific physical features (phenotype) associated with this chromosomal disorder. Common symptoms that can potentially occur include language-based learning disabilities, developmental dyspraxia, tall stature, low muscle tone (hypotonia), and abnormal bending or curving of the pinkies toward the ring fingers (clinodactyly). Trisomy X occurs randomly as a result from errors during the division of reproductive cells in one of the parents. This disorder occurs in one in 900 to 1,000 live births.

    Resources

    March of Dimes Birth Defects Foundation
    1275 Mamaroneck Avenue
    White Plains, NY 10605
    Tel: (914)997-4488
    Fax: (914)997-4763
    Tel: (888)663-4637
    Email: Askus@marchofdimes.com
    Internet: http://www.marchofdimes.com

    National Dissemination Center for Children with Disabilities (DELETED
    1825 Connecticut Ave NW, Suite 700
    Washington, DC 20009
    USA
    Tel: (202)884-8200
    Fax: (202)884-8441
    Tel: (800)695-0285
    TDD: (800)695-0285
    Email: nichcy@aed.org
    Internet: http://www.nichcy.org

    National Center for Learning Disabilities
    381 Park Avenue South
    1420 Suite
    New York, NY 10016
    Tel: (212)545-7510
    Fax: (212)545-9665
    Tel: (888)575-7373
    Email: ncld@ncld.org
    Internet: http://www.ncld.org/

    Chromosome Disorder Outreach, Inc.
    P.O. Box 724
    Boca Raton, FL 33429-0724
    USA
    Tel: (561)395-4252
    Fax: (561)395-4252
    Email: info@chromodisorder.org
    Internet: http://www.chromodisorder.org/CDO/

    Learning Disabilities Association of America
    4156 Library Road
    Pittsburgh, PA 15234-1349
    Tel: (412)341-1515
    Fax: (412)344-0224
    Tel: (888)300-6710
    Email: info@ldaamerica.org
    Internet: http://www.ldanatl.org

    International Dyslexia Association
    40 York Rd
    4 Florr
    Baltimore, MD 21204
    USA
    Tel: (410)296-0232
    Fax: (410)321-5069
    Tel: (800)222-3123
    Email: info@interdys.org
    Internet: http://www.interdys.org

    UNIQUE - Rare Chromosome Disorder Support Group
    P.O. Box 2189
    Caterham
    Surrey, CR3 5GN
    United Kingdom
    Tel: 4401883330766
    Fax: 4401883330766
    Email: info@rarechromo.org
    Internet: http://www.rarechromo.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Klinefelter Syndrome & Associates
    P.O. Box 872
    Pine, CO 80470-0872
    Tel: (303)400-9040
    Fax: (303)838-0753
    Tel: (888)999-9428
    Email: info@genetic.org
    Internet: http://www.genetic.org

    Focus Foundation, Inc.
    PO Box 190
    Davidsonville, MD 21035
    Tel: (443)223-7323
    Fax: (410)798-4801
    Email: info@thefocusfoundation.org
    Internet: http://www.thefocusfoundation.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 4/1/2014
    Copyright 1995, 1996, 1997, 1998, 2001, 2011, 2014 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

    Today on WebMD

    child with red rash on cheeks
    What’s that rash?
    plate of fruit and veggies
    How healthy is your child’s diet?
     
    smiling baby
    Treating diarrhea, fever and more.
    Middle school band practice
    Understanding your child’s changing body.
     

    worried kid
    fitArticle
    jennifer aniston
    Slideshow
     
    Measles virus
    Article
    sick child
    Slideshow
     

    babyapp
    New
    Child with adhd
    Slideshow
     
    rl with friends
    fitSlideshow
    Syringes and graph illustration
    Tool