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Mumps Vaccine Good, Not Perfect

2006 Mumps Outbreak Biggest in 20 Years Despite Vaccination

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The two-dose vaccine seemed so effective that the U.S. set a goal of eliminating mumps by 2010. The current outbreak has upset that plan.

"This outbreak was unexpected. We were down to very, very low levels of mumps in the country, and we are still trying to understand why it occurred," Seward says. "The problem is some waning of immunity after two doses, but we right now we are just watching the epidemiology very carefully to consider policy changes that might be needed."

Would the CDC consider recommending a routine third dose of mumps vaccine?

"We see no need for a routine third dose. The cost benefit would not be there," Seward says. "But if we see again some outbreaks starting and continuing, we would at that point start a third dose in an outbreak setting to see if it limited the outbreak. But it would have to be a large outbreak on a lot of college campuses to show a benefit."

Seward and colleagues report their findings in the April 10 issue of The New England Journal of Medicine.

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