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How Do Bile Acid Resins Work?

These drugs work inside the intestine, where they bind to bile from the liver and prevent it from being reabsorbed into the circulatory system. Bile is made largely from cholesterol, so these drugs work by depleting the body's supply of cholesterol. The most common side effects are constipation, gas and upset stomach. Examples of bile acid resins include:

  • Questran and Questran Light
  • Colestid
  • WelChol

How Do Fibrates Work?

Fibrates reduce the production of triglycerides and can increase HDL cholesterol. Examples of fibrates include:

  • Atromid
  • Tricor
  • Lopid

Ezetimibe (Zetia) lowers bad LDL cholesterol by blocking cholesterol absorption in the intestine. Research studies have not found that ezetimibe is associated with a lower risk of heart disease.

Combination Drugs for Cholesterol Lowering

Some people with high cholesterol, other cholesterol problems, or some other medical conditions, achieve the best results with combination drugs -- pills that contain more than one medication. Some examples include:

Advicor: Lovastatin and niacin ( nicotinic acid)

Caduet: Atorvastatin and
amlodipine, a calcium channel blocker

Liptruzet: A
torvastatin and ezetimibe 

Simcor: Simvastatin and niacin (nicotinic acid)

Vytorin: Simvastatin and
ezetimibe, a cholesterol absorption inhibitor

 









 

 

What Are the Side Effects of Cholesterol-Lowering Drugs?

The side effects of cholesterol-lowering drugs may include:

  • Muscle aches*
  • Abnormal liver function
  • Allergic reaction (skin rashes)
  • Heartburn
  • Dizziness
  • Abdominal pain
  • Constipation
  • Decreased sexual desire
  • Flushing with nicotinic acid

*If you have muscle aches, call your doctor immediately. This could be a sign of a life-threatening condition.

Are There Foods or Other Drugs I Should Avoid While Taking Cholesterol-Lowering Medicine?

You should limit grapefruit juice and fresh grapefruit consumption while taking statins, as grapefruit can interfere with the liver's ability to metabolize these medications. Talk with your doctor about your other medications, as it may be appropriate to adjust the dosing of your cholesterol medication depending on interactions.

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WebMD Video Series

Click here to wach video: LDL or HDL: What's the Difference?

Jonathan Sackner Bernstein, MD, talks about the different types of cholesterol and how they affect your health.

Click here to watch video: LDL or HDL: What's the Difference?