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Despite Study, Docs Still Like Statins

Big Trial Fails to Support Earlier Studies That Show Statins Work
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WebMD Health News

Dec. 17, 2002 -- Whoops. A major study was supposed to prove that cholesterol-lowering statin drugs save lives. It didn't.

The report, in the Dec. 18 issue of the Journal of the American Medical Association, looks at the much-used statin sold as Pravachol. It finds that the drug doesn't reduce either heart disease or death in a cross-section of older people whose high blood pressure is under control and who have moderately high cholesterol levels.

Does this mean statins don't work -- or that Pravachol isn't as good as other statins? No, experts say. Study leader Barry R. Davis, MD, PhD, of the University of Texas-Houston Health Science Center, urges patients with high cholesterol to keep taking their medicine, whether it is Pravachol or another statin.

"The bottom line is that cholesterol-treatment guidelines should remain the same," Davis tells WebMD. "This study says that people who are on statins should remain on them. All studies show statins are good at lowering cholesterol and that it is good to lower cholesterol to avoid heart disease and death."

The study looked at 10,355 people age 55 or older enrolled in a study comparing different kinds of blood-pressure drugs. All had too-high levels of LDL cholesterol -- the "bad" kind of cholesterol. About half the patients got Pravachol while the other half got "usual care." Usual care meant being placed on a specific national guidelines cholesterol-lowering diet.

Pravachol did what it is supposed to do. Patients who took the drug saw their LDL cholesterol levels fall by 28%. But those in the usual-care group had their LDL cholesterol levels drop by 11%. The end result: the Pravachol patients had about the same rate of death and heart disease as the usual-care group after nearly five years.

What happened? When the study began in the early 1990s, "usual care" didn't mean taking statins. That changed over the course of the study. It was an open-label study, in which patients knew what they were and weren't taking. Nearly a third of the usual-care patients started taking the lipid-lowering drugs -- particularly those at highest risk of heart disease. At the same time, many patients getting statins stopped taking their medication.

Accompanying the study in JAMA is an editorial by Richard C. Pasternak, MD, associate professor of medicine at Harvard University and director of preventive cardiology at Massachusetts General Hospital, Boston. Pasternak notes that the open-label study is much closer to real life than a placebo-controlled trial. He says it shows that doctors have to do a better job of making sure their patients take their medicine.

"We have a huge problem -- a compliance epidemic," Pasternak tells WebMD. "People stop taking their statins. It's no one thing; there are a dozen different reasons for different people in different places. Research suggest that in people without active heart disease, half stop taking their stains only six months after their first prescription. After two years, only a third are still taking their pills. That is what we need to focus on."

So what's the bottom line? Davis and Pasternak wholeheartedly agree: If you lower your cholesterol to recommended levels, you'll significantly lower your chances of heart disease and death. Treatment with statins can help many patients reach these lower cholesterol levels. Have a question about high blood pressure? Now's your chance to get it answered by the experts. Ask our Personal Reporter.

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Congratulations! Your total cholesterol level is in the Desirable range, and your level of "bad" LDL cholesterol is near optimal.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is borderline high. If your LDL goes higher, your total cholesterol level could become Borderline High. Consider reducing the amount of foods you eat with saturated fats and increasing physical activity. If you get more exercise, your level of "good" HDL cholesterol may increase, which could also help to keep your levels of LDL and total cholesterol in check.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL. The HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is Very High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL because the HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is Borderline High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. But your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol is High, but your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol is High, but your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is Borderline High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe medication, such as statins. Following medication, dietary, and exercise instructions should result in improvements.

Your total cholesterol level is High, and your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe statins or other cholesterol-lowering medications.

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