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Noni Juice: Can It Lower Cholesterol?

Study of Smokers Indicates Health Benefits; Experts Call for More Research
By
WebMD Health News
Reviewed by Louise Chang, MD

March 2, 2006 - Early research suggests that a commercially available juice made from a plant used for centuries in Polynesian folk medicine may have heart-healthy benefits, but all agree that larger studies are needed to confirm the finding.

Researchers report that significant reductions in total cholesterol and triglycerides were seen in smokers who drank a product containing juice from the fruit of the noni tree every day for a month. The study was funded by the manufacturer of the product, sold as Tahitian Noni Juice.

The study was presented Thursday at the 46th Annual Epidemiology Conference of the American Heart Association.

American Heart Association spokeswoman Barbara Howard, PhD, called the findings intriguing and said the study is a rare example of good research on a dietary supplement or food that makes health claims.

"Supplement stores are full of products that make health claims that aren't backed up by science," she tells WebMD. "This study was only a first step, but it is a step in the right direction."

Reductions Substantial

Researcher Mian-Ying Wang, MD, says she first became interested in studying noni juice in 1999 after becoming convinced that it helped reduce her pain from a wrist fracture.

She has received more than $800,000 in grants from Utah-based Morinda Corp., which sells the juice via the Internet and through independent distributors. The cholesterol/triglyceride research came from a larger cancer prevention study involving adult smokers.

A total of 106 smokers drank 1 to 4 ounces of the product, made from the juices of the noni plant, blueberries, and grapes, every day for a month. Twenty-six additional smokers drank a similar-tasting juice drink that did not contain noni juice. None of the participants were on cholesterol-lowering medications.

Total cholesterol levels in the noni juice drinkers dropped from 235.2 mg/dL to 190.2 mg/dL after a month; average triglyceride (blood fat) levels dropped from 242.5 mg/dL to 193.5 mg/dL. Cholesterol and triglycerides did not have any significant change during the period in the group that got the drink without noni juice.

Wang tells WebMD that she hopes to do larger studies in both smokers and nonsmokers.

Safety Concerns

Howard expressed concern that the study presented by Wang included no safety data. Noni juice is high in potassium, which can be dangerous to people with chronic kidney disease. As a result, the American Kidney Foundation has listed it as potentially harmful for kidney patients.

"Large studies are needed involving thousands of people, and the basic safety research in animals and humans needs to be done before we really understand the risks vs. benefits of this product," Howard says.

There have also been published case reports of patients who suffered liver damage while taking noni juice.

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Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is Borderline High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. But your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol is High, but your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol is High, but your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is Borderline High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe medication, such as statins. Following medication, dietary, and exercise instructions should result in improvements.

Your total cholesterol level is High, and your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe statins or other cholesterol-lowering medications.

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