Skip to content
My WebMD Sign In, Sign Up

Cholesterol & Triglycerides Health Center

Font Size

Statin Drugs: Heart Benefits Last Long

Cholesterol-Lowering Drugs Turn Back Clock on Heart Disease

Lower LDL Cholesterol = Less Heart Disease, Death continued...

This doesn't mean that the men should have stopped taking statins. Although five years of treatment offered a long-lasting benefit, the men's heart attack and heart death rates were much lower during the time they were taking their medicine.

"This suggests to us that although the benefit of those years was not lost, one would continue to get benefit from taking the statins," Cobbe says.

The study eased concern that statin treatment might increase cancer risk.

"There has been a long-running controversy over whether statins increase other diseases. The one that has generated the most discussion is whether these drugs increase the risk of cancer," Cobbe says. "Here we have a chance to see the effect on cancer a decade after treatments were finished. And we saw no evidence at all of a cancer effect."

An End to Heart Disease?

It's not the first time a study has suggested that early reductions in LDL cholesterol prevent heart disease. NIH researcher Domanski points to a 2006 study that looked at people with rare mutations in a gene called PCSK9.

The PCSK9 gene encodes a molecule that reduces the number of LDL cholesterol receptors in the liver. Think of these receptors as cholesterol drains. They are the main way the body gets rid of bad cholesterol. The more of these receptors a person has, the lower that person's LDL cholesterol level.

The 2006 study showed that people who carried certain PCSK9 gene variants had somewhat lower cholesterol levels than people with normal PCSK9 genes -- 28% lower LDL for one gene variant and 15% lower LDL for another variant.

But because they had these relatively modest LDL cholesterol reductions from the time they were born, people who carried the gene variants had far lower risk of heart disease -- 88% lower risk for one gene variant, and 47% lower risk for the other.

Moreover, Domanski points out, heart disease is almost unknown in people who live in hunter/gatherer societies that traditionally consume few saturated fats. Once these people adopt modern lifestyles, however, they have the same risk of heart disease as people living in Western cultures.

"It is a very different thing to prevent heart disease than to prevent cardiac events in people who already have heart disease," Domanski says. "If you started lowering LDL cholesterol early -- before someone has coronary artery disease -- you could get very big effects. The potential of LDL lowering, instituted early in life needs, much more research."

Domanski isn't suggesting that we put statin drugs in the water supply. But he does think a clinical trial of statin drugs, in a healthy group of people 30 to 40 years old, is worth the effort. If modest LDL cholesterol reduction early in life could cut heart disease by 50% or more, the impact would be huge.

Is This Normal? Get the Facts Fast!

Is Your Cholesterol Level Heart Healthy?
What is your LDL (low-density lipoprotein) level?

Get the latest Cholesterol Management newsletter delivered to your inbox!


or
Answer:
Desirable
0-199
Borderline
200-239
High
240+

Your level is currently

Congratulations! Your total cholesterol level is in the Desirable range, and your level of "bad" LDL cholesterol is optimal.

Congratulations! Your total cholesterol level is in the Desirable range, and your level of "bad" LDL cholesterol is near optimal.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is borderline high. If your LDL goes higher, your total cholesterol level could become Borderline High. Consider reducing the amount of foods you eat with saturated fats and increasing physical activity. If you get more exercise, your level of "good" HDL cholesterol may increase, which could also help to keep your levels of LDL and total cholesterol in check.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL. The HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is Very High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL because the HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is Borderline High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. But your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol is High, but your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol is High, but your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is Borderline High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe medication, such as statins. Following medication, dietary, and exercise instructions should result in improvements.

Your total cholesterol level is High, and your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe statins or other cholesterol-lowering medications.

Start Over

Step:  of 

Today on WebMD

woman pulling supplements from shelf
Can they help lower yours?
bowl of yogurt with heart shape
What it can do for you.
 
woman exercising
14 practical tips.
chocolate glazed donut and avocado
What your levels mean.
 
Heart Foods Slideshow
Slideshow
Cholesterol Fact or Fiction
Quiz
 
Food & Fitness Planner
TOOL
Attractive salad
ARTICLE
 
Heart Disease Overview Slideshow
SLIDESHOW
worst sandwich slideshow
SLIDESHOW
 
Fat Foods Fit Foods
SLIDESHOW
Bad Cholesterol
VIDEO
 

WebMD Special Sections