Skip to content

Cholesterol & Triglycerides Health Center

Good Cholesterol May Lower Risk of Alzheimer’s Disease

Heart-Healthy HDL Cholesterol May Also Protect Brain From Dementia
Font Size
A
A
A
By
WebMD Health News
Reviewed by Louise Chang, MD

Dec. 13, 2010 -- Having higher HDL, or “good” cholesterol, may reduce the risk of Alzheimer’s disease, new research suggests.

Experts say the new study, which was published Monday in the Archives of Neurology, is further evidence of a link between heart disease and dementia, and if the finding is backed by more research, doctors think it may point to a way that people can reduce their risk of both brain and heart trouble later in life, by boosting HDL.

“If you do things for your coronary vascular health, it clearly appears to modify your Alzheimer’s risk as well in a way we don’t completely understand.” says James R. Burke, MD, PhD, associate director of the Bryan Alzheimer’s disease research center at Duke University in Durham, N.C., who was not involved in the study.

“It’s been clearly demonstrated that you can have a big bang for your buck in terms of your heart with HDL, and now there’s initial evidence, at least, that people who have the lowest levels of HDL at least are at a significantly increased of Alzheimer’s disease, and perhaps if you modify that, then you would modify your risk,” Burke says.

HDL and Alzheimer’s Disease

Researchers at Columbia University in New York followed 1,130 seniors who had no history of memory trouble or dementia.

Every 18 months for an average of four years, participants got a battery of blood, brain, and memory tests. By the study’s end, doctors had diagnosed 101 cases of suspected Alzheimer’s disease.

When researchers compared the cholesterol levels of study participants with and without Alzheimer’s, they found that those with the highest HDL counts, over 55 mg/dL, had about a 60% reduced risk of developing the disease compared to those whose levels were under 39 mg/dL.

“Basically, what we found is that higher levels of good cholesterol decrease the risk of Alzheimer’s disease,” says study author Christiane Reitz, MD, PhD, assistant professor of Neurology at Columbia University’s Taub Institute.

Reitz and her team also found that people with high LDL, or “bad” cholesterol, and high total cholesterol had a decreased risk of developing dementia, but when they took into account other conditions known to increase the risk of Alzheimer’s, like diabetes, high blood pressure, obesity, or a genetic predisposition, LDL and total cholesterol were no longer significant predictors in their own right.

“HDL was the only one which actually stayed significant and was not explained by any of the other risks factors,” Reitz says. “For HDL it seems to be an independent association with Alzheimer’s disease with, independent of diabetes, high blood pressure and so on.”

Is This Normal? Get the Facts Fast!

Is Your Cholesterol Level Heart Healthy?
What is your LDL (low-density lipoprotein) level?

Get the latest Cholesterol Management newsletter delivered to your inbox!


or
Answer:
Desirable
0-199
Borderline
200-239
High
240+

Your level is currently

Congratulations! Your total cholesterol level is in the Desirable range, and your level of "bad" LDL cholesterol is optimal.

Congratulations! Your total cholesterol level is in the Desirable range, and your level of "bad" LDL cholesterol is near optimal.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is borderline high. If your LDL goes higher, your total cholesterol level could become Borderline High. Consider reducing the amount of foods you eat with saturated fats and increasing physical activity. If you get more exercise, your level of "good" HDL cholesterol may increase, which could also help to keep your levels of LDL and total cholesterol in check.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL. The HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is in the Desirable range, but your level of "bad" LDL cholesterol is Very High. This may mean that your level of high-density lipoprotein (HDL), or "good" cholesterol, is too low. It is best to have a high level of "good" HDL and a low level of "bad" LDL because the HDL helps keep your LDL level in check. Ask your doctor for your HDL level. If your HDL is low, increasing your physical activity can increase it, which may help reduce your LDL level.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High, but fortunately your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have other non-measured increases in LDL-like particles that can increase heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is Borderline High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. Your level of "bad" LDL cholesterol is High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is Borderline High. But your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol is High, but your level of "bad" LDL cholesterol is optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol is High, but your level of "bad" LDL cholesterol is near optimal. This could mean you have a high level of high-density lipoprotein, or "good" HDL cholesterol, which protects against heart disease. Or you could have elevated secondary lipids, such as non-HDL particles that increase the risk of heart disease. Your LDL level also could be optimal if you are taking a statin medication. Please check with your doctor to get your complete lipid profile and see if you may need additional treatment. In the meantime, find more information on WebMD's Cholesterol Health Center.

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is Borderline High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels!

Your total cholesterol level is High. Your level of "bad" LDL cholesterol is High, too. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe medication, such as statins. Following medication, dietary, and exercise instructions should result in improvements.

Your total cholesterol level is High, and your level of "bad" LDL cholesterol is Very High. Working to bring down your total cholesterol decreases your LDL cholesterol level. You can do this by exercising more and eating less food with saturated fats. Check food labels! If you are struggling to bring down your total cholesterol and LDL cholesterol levels, your doctor may prescribe statins or other cholesterol-lowering medications.

Start Over

Step:  of 

Today on WebMD

woman pulling supplements from shelf
Can they help lower yours?
bowl of yogurt with heart shape
What it can do for you.
 
woman exercising
14 practical tips.
chocolate glazed donut and avocado
What your levels mean.
 
Heart Foods Slideshow
Slideshow
Cholesterol Fact or Fiction
Quiz
 
Food & Fitness Planner
TOOL
Attractive salad
ARTICLE
 
Heart Disease Overview Slideshow
SLIDESHOW
worst sandwich slideshow
SLIDESHOW
 
Fat Foods Fit Foods
SLIDESHOW
Bad Cholesterol
VIDEO
 

WebMD Special Sections