Health Highlights: May 6, 2013
Pfizer Offers Viagra Online; FDA Criticized for OK'ing Combo Cholesterol Pill; Veterans at Higher Risk for Traffic Crashes
WebMD News Archive
Merck's new drug combines the generically available ingredient (atorvastatin) in Pfizer's Lipitor with Merck's Zetia (ezetimibe). While Zetia does lower "bad" LDL cholesterol linked with heart attacks and strokes, it is no more effective than drugs such as Lipitor, Crestor, or simvastatin, according to Forbes.com.
Unlike those other medicines, there is no evidence that Zetia prevents heart attacks or strokes, and there is no proof that Liptruzet prevents heart attacks, strokes or other cardiovascular events better than atorvastatin alone, according to Forbes.com.
A 2008 study failed to show that the combination of Zetia and simvastatin prevented artery hardening better than simvastatin alone.
A large study comparing the Zetia/simvastatin combination to simvastatin alone for preventing heart attacks, strokes and deaths is not due to be completed until late 2014 and many experts expected that the FDA would not consider approval of Liptruzet until the study was completed, Forbes.com reported.
Dr. Steven Nissen, chairman of cardiology at the Cleveland Clinic and a longtime critic of Zetia, blasted the FDA's approval of Liptruzet.
"I find it astonishing that after all the controversy about ezetimibe the FDA would approve another combination product with a drug that has been on the market for a decade and has not been shown to improve cardiovascular outcomes," he told Forbes.com.
"It seems like the agency is just tone deaf to the concerns raised by many members of the community about approving drugs with surrogate endpoints like cholesterol without evidence of a benefit for the disease we are truly trying to treat -- cardiovascular disease," he said.
Nissen said the drugs can be prescribed separately if doctors want patients to have both of them. But due to the FDA's approval of the combination pill Liptruzet, it may be discovered that Zetia really doesn't prevent heart problems only after the medicine has become even more widely used.
Merck spokeswoman Pamela Eisele told Forbes.com that the company is "confident in ezetimibe and in the established relationship between lowering LDL cholesterol and reducing cardiovascular events."
Veterans at Higher Risk for Traffic Crashes
U.S. veterans of the Iraq and Afghanistan wars who have left military service have a 75 percent higher rate of fatal traffic crashes than civilians, according to The Washington Post.
It also said that veterans who have done multiple tours to combat zones are at highest risk for traffic crashes and that troops still in uniform are more likely to have traffic crashes in the months immediately after returning from deployment than in the months immediately before.
One explanation for the findings is that soldiers continue with driving habits that could prove lifesaving in war zones but are dangerous on America's roads. These behaviors include straddling lanes, racing through intersections, swerving on bridges and not wearing seat belts because they slow escape from the vehicle, The Post reported.