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Possible New Cause of Chronic Fatigue Syndrome Identified

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"It would be very unusual for anandamides to cause pain," says Goldstein. "There's a lot of articles about it reducing pain, but I can't even think of one showing it causing pain. ... I can't see anandamide increasing pain unless there is something else wrong making the anandamide not work properly. ... Anandamides suppress the immune system, and in people with CFS, for the most part, ... you have immune activation, not immune suppression. That's why almost everyone with CFS has allergies, for example. ... So many things [in this research] are the opposite of what they should be if anandamide was increased."

Goldstein is even skeptical about the role of the delta-hemolysin toxin. "There have been so many microorganisms purported to be associated with CFS that it's like the bug-of-the-month club," he says.

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