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Stomach Virus Could Trigger CFS

Enterovirus Found in Many Chronic Fatigue Syndrome Sufferers
By
WebMD Health News
Reviewed by Louise Chang, MD

Chronic Fatigue Syndrome Virus

Sept. 13, 2007 - A group of viruses known to cause respiratory and gut infections may also be a major trigger for chronic fatigue syndrome (CFS).

In a newly published study, four out of five CFS patients showed evidence of chronic enterovirus infection in stomach tissue biopsies, compared with just one in five healthy people.

Enteroviruses are very common, second only to the common cold viruses as the most common viral infections in humans, according to the CDC. Most people who are infected with an enterovirus have no symptoms at all.

California infectious disease specialist John Chia, MD, says his findings point to chronic infection with the virus as a possible cause of chronic fatigue syndrome in a large percentage of patients.

But a longtime CFS researcher says the complex disorder is not likely to be so easily explained.

James Jones, MD, of the CDC’s chronic viral diseases branch, says despite extensive research, no cause-and-effect relationship between an active infectious agent and chronic fatigue syndrome has been established.

“This is an illness with a lot of different origins, and to assume that its cause is due to an infection because the symptoms are similar to an infection is a great leap,” Jones tells WebMD.

2.5% of Americans Have CFS

Early this summer, CDC researchers reported that the prevalence of chronic fatigue syndrome may be between six and 10 times higher in the U.S. than previously believed.

The major symptom of the disease is severe fatigue -- not relieved with rest -- that persists for at least six months. But patients also often complain of symptoms such as muscle and joint pain, memory and concentration problems, depression, sleep problems, headaches, sore throat, swollen lymph nodes, and/or gastrointestinal problems.

Chia, who practices medicine in Torrance, Calif., says he began researching chronic fatigue syndrome soon after his son Andrew became sick with the condition in 1997 at age 14.

“It took us a year to find out what he had,” he says.

Early efforts to find a cause for CFS focused on viruses. Jones was among the first to suggest that chronic infection with the virus that causes mononucleosis, the Epstein-Barr virus, might explain the disease.

But the failure to find persistent evidence of Epstein-Barr or any other virus in the blood of CFS patients led most researchers, including Jones, to look elsewhere for causes.

The lack of a diagnostic test for chronic fatigue syndrome also led many to dismiss it as an imaginary disorder, but recent research by CDC and others have proven that it is both real and common.

Other Conditions Lead to CFS

In previous research, Chia reported finding evidence of chronic infection in the muscles of CFS patients.

In the new study, he looked for similar evidence in stomach tissue taken from CFS patients who had the diagnostic procedure known as endoscopy, in which a long tube with a camera is inserted via the mouth into the stomach and biopsies of tissue are taken.

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