Flu Vaccine: Low Risk of Rare Disease
Study Notes "Very Low" Risk of Guillain-Barre Syndrome After Flu Vaccine
WebMD News Archive
Nov. 13, 2006 -- A new study shows there is a "very low" risk of a
rare, serious disease called Guillain-Barre syndrome in people who get flu
But the study, published in the Archives of Internal Medicine,
doesn't discourage getting the vaccine.
Guillain-Barre syndrome (GBS) is rare; flu is common. And flu vaccines are
the single best way to prevent flu, according to the CDC.
"We suggest that the decision to recommend vaccination against influenza
should primarily be guided by evidence of its benefit," write the
researchers, who include Kumanan Wilson, MD, MSc, of Canada's Toronto General
Wilson's team says people who get flu vaccines "should be advised of the
possible risk" of getting Guillain-Barre syndrome, "particularly in
light of the serious consequences of the illness."
The possible link between Guillain-Barre syndrome and flu vaccination isn't
new. The CDC recommends that people not get vaccinated if they've ever
developed Guillain-Barre syndrome within six weeks of getting a flu
About Guillain-Barre Syndrome
Guillain-Barre syndrome symptoms tend to appear quickly and worsen rapidly,
sometimes leading to paralysis.
In the disease, the body damages its own nerve cells (outside of the brain
and spinal cord), resulting in muscle weakness and sometimes paralysis.
Most people recover.
Early symptoms include weakness, tingling, and loss of sensation in the legs
that eventually spreads to the arms. Blood pressure problems, heart rhythm
problems, and breathing difficulties may occur in critical cases.
"Most people eventually recover completely or nearly completely, but
some people have permanent nerve damage, and between 5% and 6% of people who
develop GBS die," states the CDC's web site.
Wilson's team tracked Guillain-Barre syndrome hospitalizations in more than
12 million adults in Ontario, Canada, who got flu vaccines between 1992 and
The vast majority who received flu vaccinations weren't hospitalized for
Guillain-Barre syndrome during the study, but 1,601 people were.
In 269 of those cases, Guillain-Barre syndrome struck within 43 weeks
(almost 11 months) of flu vaccination.
The study doesn't prove flu vaccines caused any of the Guillain-Barre
syndrome cases. The findings "must be interpreted carefully," the
October and November are the best months to get vaccinated against flu, but
you can still get vaccinated in December or later, according to the CDC.
The CDC recommends annual flu vaccines for the following groups:
- Children aged 6 months to 5 years
- Pregnant women
- People 50 and older
- People of any age with certain chronic medical conditions
- People living in nursing homes and other long-term care facilities
- Health care workers
- People who live with those at high risk for flu complications
- Household contacts and caregivers of babies less than 6 months old.
The CDC says the following groups shouldn't get flu vaccines without first
consulting a doctor:
- People who have a severe allergy to chicken eggs
- People who have had a severe reaction to a past flu vaccine
- People who developed Guillain-Barre syndrome within six weeks of getting a
past flu vaccine
- Babies younger than 6 months
- People who have a moderate or severe illness with a fever should wait to
get vaccinated until their symptoms ease.