Major pharmaceutical companies continually research and develop new medications and treatments, which must be shown to be safe and effective before doctors can prescribe them to patients. Through colorectal cancer clinical trials, researchers test the effects of new medications on a group of volunteers with colorectal cancer. Following a strict protocol and using carefully controlled conditions, researchers evaluate the investigational drugs under development by measuring the ability of the new drug to treat colorectal cancer, its safety, and any possible side effects.
Some patients with colorectal cancer are reluctant to take part in clinical trials for fear of getting no treatment at all for their colorectal cancer. This is simply not true. Patients with colorectal cancer who participate in colorectal cancer clinical trials receive the most effective therapy currently available for the colorectal cancer -- or they may receive colorectal cancer treatments that are being evaluated for future use. These colorectal cancer drugs may be even more effective than the current colorectal cancer treatment. The only way to determine if a newer therapy is better than a currently available therapy is by clinical trial participation.
Note: Separate PDQ summaries on Colorectal Cancer Screening; Colon Cancer Treatment; and Rectal Cancer Treatment are also available.
Factors Associated With Increased Risk of Colorectal Cancer
Excessive alcohol use
Based on solid evidence from observational studies, excessive alcohol use is associated with an increased risk of colorectal cancer (CRC).[1,2,3]
Magnitude of Effect: A pooled analysis of eight cohort studies estimated an adjusted relative risk (RR) of 1.41 (95% confidence...
This web site, developed by the nonprofit Coalition of Cancer Cooperative Groups, is an unbiased cancer clinical trial matching and navigation service enabling patients to search for cancer trials based on disease and location.