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    New Pill May Screen for Colon Cancer

    Early Colon Imaging Capsule Results ‘Encouraging’
    WebMD Health News
    Reviewed by Louise Chang, MD

    May 22, 2007 -- In the future, getting screened for colon cancer may be as simple as taking a pill.

    Researchers say they are encouraged by early results from an ongoing study comparing a pill-delivered imaging device with colonoscopy for detection of colon polyps and colon cancer screening. Colon polyps are growths that can become cancerous.

    Similar imaging devices, called PillCams, are already being used to screen for esophageal and small intestine disease.

    But it is not yet clear if the same technology will prove to be a useful tool for colon cancer screening.

    The camera ‘pill’, which is the size of a large multivitamin, travels though the body capturing images along the way -- at a speed of four images per second in the case of the colon cam.

    Pill-based endoscopy requires at least as much prep to clean out the colon as is needed with colonoscopy, but the actual test involves little more from the patient than swallowing a pill.

    Not as Accurate as Colonoscopy

    Interim findings from an ongoing European trial with a target of 329 patients were presented Tuesday in Washington at an international meeting of digestive disease specialists.

    Researcher Jacques Deviere, MD, of Brussel’s Erasme University Hospital reported on results from 84 patients who had the capsule imaging procedure followed by colonoscopy screening.

    Standard preparation techniques for colonoscopy screening resulted in excellent to good imaging with the ingestible endoscopy technique in two-thirds of patients and fair to poor imaging in the remaining third.

    The PillCam did not detect as many polyps as colonoscopy, but Deviere and colleagues concluded that it is accurate enough to be a useful tool for colon cancer screening.

    A spokesman for the Israeli company that makes the pill camera, Given Imaging Ltd, tells WebMD that the goal is not to replace colonoscopy, but to offer an alternative to patients who are unable or unwilling to undergo the invasive procedure.

    “It is not quite as good as colonoscopy, but it is much easier on the patient,” says Mark Gilreath. “There is no sedation and no hospitalization.”

    Gilreath says the company hopes to win approval to sell the colon imaging device in the United States by the end of the year.

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