Aspirin Blocks Only Some Colon Cancer
Study IDs People Who Benefit Most From Aspirin Use; Could Lead to New Treatments
May 23, 2007 - New insights into how colorectal cancers develop could lead
to a targeted approach for using aspirin and other anti-inflammatory drugs to
prevent the disease.
While regular aspirin use has been shown to lower colorectal cancer risk,
the risks associated with frequent use are believed to outweigh the benefits.
Serious side effects of regular aspirin use include ulcers and bleeding of the
But a new study, led by researchers from Harvard Medical School and
Massachusetts General Hospital, raises hopes of identifying and treating only
those who would benefit most from aspirin therapy.
The widely held belief that aspirin lowers colorectal cancer risk by
reducing inflammation led the researchers to examine the expression of the
Cox-2 enzyme in colorectal tumors.
“Cox-2 is an enzyme that is associated with inflammation, and it has become
clear that some cancers express this enzyme and others do not,” researcher
Andrew T. Chan, MD, MPH, tells WebMD.
36% Risk Reduction
Chan and colleagues hypothesized that frequent aspirin use would protect
against colorectal cancers that expressed Cox-2, but not those that didn’t.
They tested the theory by examining the medical records of 130,000
participants in two large, ongoing health trials. They also examined the lab
reports of 600 tumor specimens from people in the studies who developed
Their findings appear in the May 24 issue of TheNew England
Journal of Medicine.
Overall, Chan and colleagues found that people who took at least two
standard aspirin tablets a week had a lower risk of developing colorectal
cancer than nonaspirin users.
But their analysis of cancer samples revealed that the risk reduction was
seen only in tumors expressing the Cox-2 enzyme.
Roughly two-thirds of the tested tumors had moderate or strong Cox-2
expression, while the remaining third did not.
Chan tells WebMD that regular aspirin use was associated with a 36%
reduction in the risk of developing Cox-2-positive tumors. Aspirin use did not
appear to influence the risk of developing Cox-2-negative tumors.
Aspirin and other Cox-2 inhibiting therapies, like the drug Celebrex, are
known to help prevent the colorectal polyps that can lead to cancer.
And like colorectal cancers, precancerous colorectal polyps express Cox-2
enzymes at different levels.
Determining the Cox-2 status of these polyps when they are removed during
cancer screening may prove to be one way of identifying at-risk people who
could benefit from preventive therapy with aspirin, Chan says.
“We definitely need to study this further,” he says. “A first step is to
confirm that the expression of Cox-2 in [precancerous polyps] has some
influence on its expression in cancer.”
Until more is known, Chan says people worried about colorectal cancer should
focus on proven prevention strategies, such as colonoscopy screening.
American Cancer Society senior epidemiologist Eric Jacobs, PhD, agrees.
“We don’t recommend aspirin for prevention because of the potential for
serious side effects,” he says. “But everybody 50 and over should get tested so
that polyps can be detected and removed before they turn into cancer. And we
know that regular exercise and maintaining a healthy weight are also excellent
ways to reduce colon cancer risk.”