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Blood Test May Spot Early Colon Cancer

Noninvasive Colon Cancer Screening May Catch More Cancers, Researchers Say
WebMD Health News
Reviewed by Laura J. Martin, MD

Sept. 29, 2010 -- A simple blood test may help identify colon cancer early, when it is in its most treatable stages.

Although the research is still in its infancy, "we are trying to develop a test that can be integrated into an annual checkup that is just another box for a doctor to check on the menu of blood tests he or she can order," says study author Søren Jensby Nielsen, PhD, the scientific manager for Diagnostic Product Development at Exiqon A/S in Copenhagen, Denmark. Exiqon is developing the new screening test and technology.

Nielsen presented his findings at the Fourth American Association for Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development in Denver.

Researchers used cutting-edge technology to analyze blood samples taken from people with early stage colon cancer and people without colon cancer. They identified a specific biomarker profile in the blood samples that could help identify people with colon cancer earlier and less invasively than with colonoscopy. The study focuses on short RNA molecules or microRNAs, which are found in the blood in small but detectable amounts.

"We have the potential to detect the majority of early colon cancers with this test, but we are just one year into a four-year project," he tells WebMD. "We are not saying that we can diagnose colon cancer with 100% specificity from a blood sample, but our test would be an alarm signal and if you are positive, you should have a colonoscopy," he says.

When and how frequently this blood test could be administered is still unknown. "More research is needed to validate these findings," he says. Nielson says the screening test must be validated before he can share any numbers about how specific or sensitive the new blood test is.

Regular colon cancer screening typically begins at age 50, or earlier if there are any symptoms or risk factors. The U.S. Preventive Services Task Force recommends screening for colorectal cancer using colonoscopy or other colon cancer screening tests. During a colonoscopy, a doctor guides a thin, flexible tube capped with a tiny camera through the colon to look for tumors or other abnormalities.

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