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Stage IV and Recurrent Colon Cancer

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In another study (NCT00339183), patients with metastatic colorectal cancer who had already received a fluoropyrimidine regimen were randomly assigned to either FOLFIRI or FOLFIRI plus panitumumab.[78] In a post hoc analysis, patients with KRAS wild-type tumors experienced a statistically significant PFS advantage (HR = 0.73; 95% CI, 0.59-0.90; P = .004, stratified log-rank).[78] [Level of evidence: 1iiDiii] Median PFS was 5.9 months (95% CI, 5.5 months-6.7 months) for panitumumab-FOLFIRI and 3.9 months (95% CI, 3.7 months-5.3 months) for FOLFIRI alone. OS was not significantly different. Patients with mutant KRAS tumors experienced no benefit from the addition of panitumumab.

It is unproven whether these EGFR agents should be combined or used in a sequential approach.

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV colon cancer and recurrent colon cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

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