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Rectal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage 0 Rectal Cancer

Stage 0 rectal cancer is the most superficial of all rectal lesions and is limited to the mucosa without invasion of the lamina propria. Because of its superficial nature, surgical and other procedures may be limited.

Standard treatment options:

Recommended Related to Colorectal Cancer

Cellular Classification and Pathology of Rectal Cancer

The World Health Organization (WHO) classification of tumors of the colon and rectum include the following:[1] Epithelial Tumors Adenoma Tubular. Villous. Tubulovillous. Serrated. Intraepithelial neoplasia (dysplasia) associated with chronic inflammatory diseases Low-grade glandular intraepithelial neoplasia. High-grade glandular intraepithelial neoplasia. Carcinoma Adenocarcinoma. Mucinous adenocarcinoma. Signet-ring...

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  1. Local excision or simple polypectomy.[1]
  2. Full-thickness rectal resection by the transanal or transcoccygeal route for large lesions not amenable to local excision.
  3. Endocavitary radiation therapy.[2,3,4]
  4. Local radiation therapy.[2]

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage 0 rectal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

References:

  1. Bailey HR, Huval WV, Max E, et al.: Local excision of carcinoma of the rectum for cure. Surgery 111 (5): 555-61, 1992.
  2. Kodner IJ, Gilley MT, Shemesh EI, et al.: Radiation therapy as definitive treatment for selected invasive rectal cancer. Surgery 114 (4): 850-6; discussion 856-7, 1993.
  3. Mendenhall WM, Rout WR, Vauthey JN, et al.: Conservative treatment of rectal adenocarcinoma with endocavitary irradiation or wide local excision and postoperative irradiation. J Clin Oncol 15 (10): 3241-8, 1997.
  4. Aumock A, Birnbaum EH, Fleshman JW, et al.: Treatment of rectal adenocarcinoma with endocavitary and external beam radiotherapy: results for 199 patients with localized tumors. Int J Radiat Oncol Biol Phys 51 (2): 363-70, 2001.
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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