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Can antidepressants help get the serotonin in your brain back in sync?

Psychiatrist, WebMD Medical Expert
American Medical Association

Serotonin is one of a few chemicals that may not function properly in depression. But clinical  depression may be due to genetics, stress, or your personality or coping style. Some of us think that psychotherapy actually exercises the front of the brain, which helps to improve the functioning of brain circuits that regulate mood.  So psychotherapy can change brain functioning. If therapy specific to depression  has  helped you, keep doing it. If it fails to help, then a med may be called for. Unfortunately,  the more depressive episodes  someone has, the more likely the illness will recur again in the future, and long-term, ongoing medications are often then considered to be the standard of care.