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Depression Health Center

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How Long Should You Take Antidepressants?

Getting the Most From Depression Medication

“People notoriously quit treatment too soon,” says Jon Allen, PhD, senior staff psychologist at Menninger Clinic in Houston. “They start to feel better so they stop taking medication, quit therapy, and even end hospitalization early. The best thing you can do it stick with it. Persistence is what makes all the difference.”

To treat your depression most effectively, follow these tips when starting and stopping medication:

  • Give an antidepressant time to work. “Antidepressants can take a few weeks to a couple of months before they take full effect,” says David Brendel, MD, PhD, assistant professor of psychiatry at Harvard Medical School and associate medical director for the Pavilion at McLean Hospital in Belmont, Mass. Don’t expect an antidepressant to make you feel better immediately.
  • Take depression medicine exactly as prescribed. Taking less medication or skipping doses will make an antidepressant less effective. If you experience troublesome side effects, be sure to tell your doctor right away.
  • Don’t go off antidepressants on your own. “Stopping a medication should be done only with a doctor’s supervision,” Brendel tells WebMD. “Some medications can have very unpleasant withdrawal side effects. Once it is time to come off the drug, your doctor will help you slowly and safely taper off by gradually reducing the dose over time.”
  • Don’t give up if one medication isn’t helping your depression. Your doctor will likely be able to prescribe another antidepressant if the one you’re taking doesn’t seem to be working for you. A National Institute of Mental Health study found that people with depression who did not respond to a first medication had a better chance of recovery if they tried a second type or added a new one to their treatment. So it’s worth the effort to find a medication that works for you.
  • Continue taking antidepressant medicine even when you start to feel better. Although it may be tempting to stop medication as your mood lifts, continue taking it for as long as your doctor recommends. Most doctors advise patients to take antidepressants for six months to a year after they no longer feel depressed. Stopping before that time can cause depression to return.

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