Antidepressants are some of the best treatments we have for depression. But these drugs don't cure depression in the way that antibiotics cure infections. Instead, they can help ease the symptoms.
You will probably need to continue medication even after you feel better. The American Psychiatric Association recommends that people keep taking their medicine for four to five months after they recover from a first episode of depression and often longer (sometimes even indefinitely) for people who have had multiple previous depressions. This helps reduce the risk of relapse.
Five years ago, after ending a long-term relationship, Anita became seriously depressed. It benched the once-physically active writer, who asked that her last name be withheld to protect her privacy.
She stopped running and began gaining weight and falling out of shape. It was not the first time she had been depressed, and traditional therapy had not helped her as much as she had hoped. This time, she sought out someone different. She found Jane Baxter, PhD, a therapist who was able to get her moving...
Depression can sometimes be like any chronic illness, like diabetes or heart disease, and may need ongoing treatment. This is called maintenance treatment.
Here is a rundown of some of the most common medicines used to treat depression and prevent it from coming back.
In the past two decades, many new types of antidepressants have become available, each working in slightly different ways.
Selective serotonin reuptake inhibitors (SSRIs) affect the levels of a chemical in your brain called serotonin. This class of antidepressants include Celexa (citalopram), Lexapro (escitalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline). Another SSRI, Viibryd, was approved by the FDA in early 2011. Side effects of most SSRIs are generally mild. They include stomach upset, sexual problems, insomnia, dizziness, weight change, and headaches.
Serotonin and norepinephrine reuptake inhibitors (SNRIs) affect levels of both serotonin and another brain chemical, norepinephrine. This class includes Cymblata (duloxetine), Effexor (venlafaxine), Fetzima (levomilnacipran), and Pristiq or Khedezla (desvenlafaxine). Side effects are usually mild. They include upset stomach, sleep problems, sexual problems, headache, anxiety, and dizziness, and weakness.
"Other" Serotonergic Drugs. A new antidepressant, Brintellix (vortioxetine) affects a number of different serotonin receptor subtypes in the brain and is therefore classified as a unique type of antidepressant.
Norepinephrine and dopamine reuptake inhibitors (NDRIs) affect norepinephrine and a different chemical in the brain, dopamine. This class of drugs includes Wellbutrin (bupropion). Side effects are usually mild, and include upset stomach, headache, sleep problems, and anxiety. Wellbutrin may be less likely to cause sexual side effects or weight gain than other antidepressants.
Noradnergic and specific serotonergic antidepressants (NaSSAs) also affect serotonin and norepinephrine in your brain. This class of drugs includes Remeron (mirtazpine). Side effects are usually mild, and include upset stomach, sleep problems, weight gain, anxiety, and dizziness.
Some of the first medicines used to treat depression were tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs). Both types affect the availability of certain neurotransmitters (chemicals in the brain) that are thought to play a role in depression. While these medicines can help, doctors don't use them as much anymore. They can have more severe safety risks due to certain drug or food interactions and also can be very dangerous in overdose. However, they are still the right choice for some people with depression -- especially if newer antidepressants don't help.
Other drugs that are not actually antidepressants can also help. For instance, some people recovering from depression will benefit from drugs for anxiety or insomnia. In addition, certain atypical antipsychotics -- such as Seroquel XR (quetiapine) or Abilify (aripiprazole) -- have been shown to enhance the effect of antidepressant medicines for depression when an antidepressant alone isn't fully effective.