You will probably need to continue medication even after you feel better. The American Psychiatric Association recommends that people keep taking their medicine for four to five months after they recover from a first episode of depression and often longer (sometimes even indefinitely) for people who have had multiple previous depressions. This helps reduce the risk of relapse.
When medication fails to ease the symptoms of clinical depression, there are other options to try. Brain stimulation techniques such as electroconvulsive therapy (ECT), for example, can be used to treat major depression that hasn't responded to standard treatments.
The least invasive of these techniques is called transcranial magnetic stimulation (TMS), in which a magnetic field is created by a device held to the forehead. causing a weak electrical signal to be applied to the prefrontal cortex,...
Norepinephrine and dopamine reuptake inhibitors (NDRIs) affect norepinephrine and a different chemical in the brain, dopamine. This class of drugs includes Wellbutrin (bupropion). Side effects are usually mild, and include upset stomach, headache, sleep problems, tremor, and anxiety. Wellbutrin may be less likely to cause sexual side effects or weight gain than other antidepressants.
Noradnergic and specific serotonergic antidepressants (NaSSAs) also affect serotonin and norepinephrine in your brain. This class of drugs includes Remeron (mirtazpine). Side effects are usually mild, and include upset stomach, sleepiness, weight gain, anxiety, and dizziness.