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Depression Health Center

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Study: SSRI Antidepressants Save Lives

Suicide Rate Dropped After New Antidepressants Were Introduced
WebMD Health News
Reviewed by Louise Chang, MD

June 12, 2006 - Far from increasing suicide risk, SSRI antidepressants have saved thousands of lives since they became available in the U.S. in the late 1980s, according to findings from a new study.

Researchers estimate that after the availability of the new generation of drugs for depressiondepression, there were 33,600 fewer suicide deaths than would have otherwise been expected between 1988 and 2002. They use mathematical probability modeling to come up with the figure.

Researcher Julio Licinio, MD, who led the study while at UCLA, is now chairman of the department of psychiatry and behavioral science at the University of Miami's Leonard M. Miller School of Medicine.

"The overall message is that on a population level these drugs are safe," he tells WebMD. "They have been prescribed in huge numbers and suicides have been going down."

Fourteen-Year Decline

The study joins a growing body of research challenging claims that the widely-prescribed selective serotonin reuptake inhibitor (SSRI) antidepressants are linked to an increased risk of suicidal thoughts and behaviors.

Researchers analyzed suicide data from the CDC and the U.S. Census Bureau from the early 1960s until 2002. They looked at deaths from suicides and did not include suicidal behaviors or suicidal feelings or thoughts in their analysis.

They found that while suicide rates remained fairly steady for the 15 years prior to introduction of Prozac (fluoxetine) in 1988, they dropped steadily over the next 14 years as sales of the drug increased.

Prozac was the first SSRI antidepressant to be sold in the U.S. and it is still the most widely prescribed antidepressant. Sales of Prozac skyrocketed from 2.5 million prescriptions in 1988 to around 33 million in 2002.

The study reports that between 12.7 and 13.7 suicides occurred among every 100,000 people in the U.S. from the early 1960s until 1988. Suicides steadily declined after that to a low of 10.4 per 100,000 in 2000.

Licinio and colleagues developed a mathematical model designed to estimate the impact of SSRI use on suicides. Based on suicide figures prior to the introduction of the antidepressants, the researchers concluded that there was a cumulative decrease in expected suicides of 33,600 from 1988 through 2002.

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