Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Depression Health Center

Font Size

Clues Help ID Depressed People at Risk of Bipolar Disorder

Depression With Periods of Increased Energy and Decreased Need for Sleep Could Raise Risk of Bipolar Disorder, Study Says
WebMD Health News
Reviewed by Laura J. Martin, MD

Aug. 17, 2010 -- Researchers have discovered clues that may help identify which people with depression are at risk of developing bipolar disorder. The new findings appear in the online version of The American Journal of Psychiatry.

Bipolar disorder is a serious condition characterized by the extreme highs of mania and devastating lows of depression. Nearly 40% of people with a history of major depression also report recurrent episodes of low level, subtle hypomania, the new study showed.

Less intense than mania, hypomania is marked by bursts of increased energy, activity, and less need for sleep. The episodes reported by nearly 40% of the study participants were not full-blown mania or even full-blown hypomania, but more mild and dubbed "sub-threshold hypomania."

"People with a history of depression who have recurrent episodes of a day or two of increased energy, activity, and decreased sleep and then go back to their usual level of function may be more likely to develop bipolar disorder in the future," says study author Kathleen Merikangas, PhD, a senior investigator and chief of the genetic epidemiology branch in the Intramural Research Program at the National Institute of Mental Health in Bethesda, Md.

"The earlier bipolar disorder is recognized and treated, the less consequences there are of manic episodes such as substance abuse and trouble with the law," she says. "These people should be monitored carefully, not just put on antidepressants."

The study included information from members of more than 5,000 households across the U.S. who participated in face-to-face interviews between February 2001 and April 2003. The interviews focused on having a history of mood disorders, their symptoms, and the severity of their symptoms.

Family History of Mania Raises Risk

Another major risk factor highlighted in this study is a family history of mania. In fact, family history of mania was as common in people with sub-threshold hypomania as it was in people with full-blown mania, the study showed.

Study participants with depression and subthreshold hypomania also developed mood disorders at a younger age and had more anxiety, substance abuse problems, and depressive episodes than their counterparts who experienced depression on its own.

"If you notice these up-and-down shifts even if they are only short lived in yourself or in a loved one with depression, seek evaluation by a mental health professional," she says. Mental health experts are more apt to recognize whether these behaviors are the seeds of bipolar disorder or people are just truly starting to feel better, Merikangas says.

Today on WebMD

Differences between feeling depressed and feeling blue.
jk rowling
Famous people who've struggled with persistent sadness.
depressed man sitting on hallway floor
Learn the truth about this serious illness.
Sad woman looking out of the window
Tips to stay the treatment course.
unhappy teen boy
Health Check
jk rowling
Pills with smiley faces
Teen girl huddled outside house
Depressed man sitting in hospital hallway
antidepressants slideshow
pill bottle
Winding path