Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Depression Health Center

Font Size

FDA OKs Viibryd to Treat Depression

New Antidepressant Gives Patients New Option for Treating Major Depressive Disorder
WebMD Health News
Reviewed by Laura J. Martin, MD

Jan. 26, 2011 -- The FDA has approved a new drug called Viibryd to treat adults with major depressive disorder.

Carol Reed, MD, chief medical officer of Clinical Data Inc., tells WebMD that Viibryd offers a new choice for doctors treating people with depression. It is the only antidepressant that is a selective serotonin reuptake inhibitor but also works as a 5HT1A receptor partial agonist, meaning it affects the brain chemical serotonin in two ways. Serotonin helps regulate mood and other processes.

“Major depressive disorder is disabling and prevents a person from functioning normally,” Thomas Laughren, MD, director of the division of psychiatry products in the FDA’s Center for Drug Evaluation and Research, says in a news release. “Medications affect everyone differently, so it is important to have a variety of treatment options available to patients who suffer from depression.”

New Treatment Option

Stephen M. Stahl, MD, PhD, professor of psychiatry at the University of California, San Diego, says in a news release that Viibryd “is an important new treatment option with proven efficacy and a demonstrated safety profile.”

In the clinical trials, Viibryd was superior to placebo in the improvement of depressive symptoms.

Viibryd was associated with adverse reactions including diarrhea, nausea, vomiting, and insomnia in some patients during clinical trials.

Other adverse effects of Viibryd included decreased libido in 4% of study participants compared to less than 1% in those taking a placebo. Erectile dysfunction was reported by 2% of study participants on Viibryd compared to 1% in people on placebo.

Like all other antidepressant medications, the drug will contain a boxed warning and a patient medication guide describing the potentially increased risk of suicidal thinking and behavior in children, adolescents, and young adults 18 to 24 during initial treatment.

The FDA says in a news release that the warning in Viibryd prescriptions also will say that data did not show an increased of suicidal thoughts in adults older than 24, and decreased risk of suicidal thinking and behavior in patients 65 and older.

Clinical Data Inc. states in a news release that it plans to make Viibryd available in the U.S. in the second quarter of this year.

Today on WebMD

Differences between feeling depressed and feeling blue.
jk rowling
Famous people who've struggled with persistent sadness.
depressed man sitting on hallway floor
Learn the truth about this serious illness.
Sad woman looking out of the window
Tips to stay the treatment course.
unhappy teen boy
Health Check
jk rowling
Pills with smiley faces
Teen girl huddled outside house
Depressed man sitting in hospital hallway
antidepressants slideshow
pill bottle
Winding path