Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Depression Health Center

Font Size

Drink Coffee, Stay Happy?

4 Cups Daily Linked With 20% Lower Risk of Depression in Women, but Mental Health Expert Urges Caution
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 26, 2011 -- Some coffee drinkers may have a reason to smile -- or keep smiling.

Drinking several cups a day is linked with a lower risk of depression, according to a new study that looked only at women. The benefit seems to start at two cups a day.

The study is published in the Archives of Internal Medicine .

"We found that women with the highest coffee intake -- those in the top 20% -- had a 20% lower risk of developing depression," says researcher Alberto Ascherio, MD, DrPH. "The top 20% drank about the equivalent of four cups of coffee per day." Ascherio is professor of epidemiology and nutrition at the Harvard School of Public Health and professor of medicine at Harvard Medical School.

The link was not found for decaffeinated coffee.

Ascherio emphasizes that he found an association, not cause and effect. Depression affects twice as many women as men, he notes. About 20% of U.S. women will be affected during their lifetime.

A mental health expert cautions that the research finding should be viewed cautiously. "I wouldn't tell my patients to drink more caffeine based on this study," says Michelle Riba, MD, associate director of the University of Michigan Depression Center. She reviewed the study but was not involved in it.

Caffeine and Depression Risk

Ascherio and colleagues evaluated more than 50,000 women, average age 63. They were participating in the long-running Nurses' Health Study.

None had any depression at the start of the investigation in 1996. All answered questions about their caffeine habits through June 2006. "Women reported their consumption of coffee and other caffeine drinks, more or less every four years," Ascherio says. They noted their usual intake over the past 12 months.

The women also reported if they had clinical depression or if they began using antidepressant medication.

During the follow-up, 2,607 women developed depression.

Overall, the more coffee they drank, the less likely they were to become depressed. "We see a dose response," Ascherio tells WebMD.

Compared with women who drank one cup or less a week, those who had two to three cups a day had a 15% lower risk of depression. Those who drank four or more had a 20% lower risk.

Today on WebMD

Differences between feeling depressed and feeling blue.
jk rowling
Famous people who've struggled with persistent sadness.
depressed man sitting on hallway floor
Learn the truth about this serious illness.
Sad woman looking out of the window
Tips to stay the treatment course.
unhappy teen boy
Health Check
jk rowling
Pills with smiley faces
Teen girl huddled outside house
Depressed man sitting in hospital hallway
antidepressants slideshow
pill bottle
Winding path