Skip to content
My WebMD Sign In, Sign Up

Depression Health Center

Font Size

Serotonin Syndrome - Topic Overview

Taking certain medicines together can cause a serious but uncommon condition called serotonin syndrome. The problem can happen if you are taking a triptan, used for migraines, along with an antidepressant medicine such as an SSRI or an SNRI.

SSRIs are selective serotonin reuptake inhibitors, and SNRIs are selective serotonin/norepinephrine reuptake inhibitors.

Recommended Related to Depression

Top 7 Therapy Myths Debunked

Many people have a perception of talk therapy that doesn't quite match up to reality. If you think therapy means lying on a couch with a box of tissues and paying top dollar to talk to someone who doesn't quite get it, or that it's only for people who are mentally ill, think again. It turns out that most people could benefit from therapy -- but it takes work on your part, a therapist who meets your needs and really does understand you, and as much time as it takes -- at your convenience and within...

Read the Top 7 Therapy Myths Debunked article > >

Symptoms of serotonin syndrome may include:

  • Restless feelings.
  • Clumsiness or loss of coordination.
  • Hallucinations (seeing or hearing things).
  • Rapid heart rate.
  • Raised body temperature.
  • Nausea.
  • Vomiting.
  • Diarrhea.

If you are taking a triptan along with an antidepressant and you notice any of these symptoms, call your doctor right away. Without treatment, serotonin syndrome can be deadly. But treatment usually can get rid of the symptoms in less than 24 hours.

1

WebMD Medical Reference from Healthwise

Last Updated: June 10, 2011
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

Today on WebMD

contemplation
Differences between feeling depressed or blue.
light therapy
What are the symptoms?
 
depressed man sitting on hallway floor
Learn the truth about this serious illness.
Sad woman looking out of the window
Tips to stay the treatment course.
 
Woman taking pill
Article
Woman jogging outside
Feature
 
man screaming
Article
woman standing behind curtains
Article
 
Pet scan depression
Slideshow
antidepressants slideshow
Article
 
pill bottle
Article
Winding path
Article